Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain
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DOI: 10.1007/s00705-017-3681-x
Abstract: An F35L mutation in the N-terminal domain of the polymerase acidic protein (PA-Nter), which contains the active site of the endonuclease, has been reported to result in higher polymerase activity in mouse-adapted strains of the… read more here.
Keywords: polymerase acidic; influenza h1n1; pandemic influenza; polymerase ... See more keywords
Bilobetin, a novel small molecule inhibitor targeting influenza virus polymerase acidic (PA) endonuclease was screened from plant extracts.
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DOI: 10.1080/14786419.2020.1808636
Abstract: The influenza A virus polymerase acidic (PA) endonuclease is an attractive target for anti-influenza drug development. In this study, plant extracts were used to screen the inhibitor against the PA endonuclease and its mutant. In… read more here.
Keywords: endonuclease; polymerase acidic; influenza virus; virus polymerase ... See more keywords
Targeted inhibition of the endonuclease activity of influenza polymerase acidic proteins.
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DOI: 10.4155/fmc-2021-0264
Abstract: Influenza is a type of acute respiratory virus infection caused by the influenza virus that occurs in epidemics worldwide every year. Due to the increasing incidence of influenza virus resistance to existing drugs, researchers are looking for… read more here.
Keywords: influenza virus; virus; endonuclease activity; polymerase acidic ... See more keywords