Antivirals targeting the polymerase complex of influenza viruses.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104545
Abstract: Current influenza antivirals have limitations with regard to their effectiveness and the potential emergence of resistance. Encouragingly, several new compounds which inhibit the polymerase of influenza viruses have recently been shown to have enhanced pre-clinical… read more here.
Keywords: complex influenza; influenza viruses; influenza; antivirals targeting ... See more keywords
Structure of the Respiratory Syncytial Virus Polymerase Complex
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.08.014
Abstract: Summary Numerous interventions are in clinical development for respiratory syncytial virus (RSV) infection, including small molecules that target viral transcription and replication. These processes are catalyzed by a complex comprising the RNA-dependent RNA polymerase (L)… read more here.
Keywords: respiratory syncytial; syncytial virus; structure; polymerase ... See more keywords
Indiscriminate activities of different henipavirus polymerase complex proteins allow for efficient minigenome replication in hybrid systems
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Virology"
DOI: 10.1128/jvi.00503-24
Abstract: ABSTRACT The henipaviruses, including Nipah virus (NiV) and Hendra virus (HeV), are biosafety level 4 (BSL-4) zoonotic pathogens that cause severe neurological and respiratory disease in humans. To study the replication machinery of these viruses,… read more here.
Keywords: replication; polymerase complex; complex proteins; niv hev ... See more keywords
Comparison of Zaire and Bundibugyo Ebolavirus Polymerase Complexes and Susceptibility to Antivirals through a Newly Developed Bundibugyo Minigenome System
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00643-21
Abstract: Ebolavirus disease is a viral infection and is fatal in 25 to 90% of cases, depending on the viral species and the amount of supportive care available. Two species have caused outbreaks in the Democratic… read more here.
Keywords: system; polymerase complex; ebolavirus; polymerase ... See more keywords
p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling
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DOI: 10.1371/journal.ppat.1010295
Abstract: Many cellular genes and networks induced in human lung epithelial cells infected with the influenza virus remain uncharacterized. Here, we find that p21 levels are elevated in response to influenza A virus (IAV) infection, which… read more here.
Keywords: polymerase; p21 restricts; perturbing viral; polymerase complex ... See more keywords
Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666180706112940
Abstract: Influenza viruses are severe human pathogens that pose persistent threat to public health. Each year more people die of influenza virus infection than that of breast cancer. Due to the limited efficacy associated with current… read more here.
Keywords: drug; polymerase; polymerase complex; influenza virus ... See more keywords
The Nucleocapsid of Paramyxoviruses: Structure and Function of an Encapsidated Template
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13122465
Abstract: Viruses of the Paramyxoviridae family share a common and complex molecular machinery for transcribing and replicating their genomes. Their non-segmented, negative-strand RNA genome is encased in a tight homopolymer of viral nucleoproteins (N). This ribonucleoprotein… read more here.
Keywords: function encapsidated; structure function; nucleocapsid paramyxoviruses; structure ... See more keywords