DNA polymerase β deficiency in the p53 null cerebellum leads to medulloblastoma formation.
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DOI: 10.1016/j.bbrc.2018.09.166
Abstract: Defects in DNA damage response or repair mechanisms during neurogenesis result in genomic instability, which is causative for several neural defects. These include brain tumors, particularly medulloblastoma, which occurs in the cerebellum with a high… read more here.
Keywords: polymerase deficiency; dna polymerase; p53 null; p53 double ... See more keywords