DNA polymerase epsilon interacts with SUVH2/9 to repress the expression of genes associated with meiotic DSB hotspot in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208441119
Abstract: Significance Meiotic recombination is essential for producing genetically diversified haploid gametes and initiates from the programmed formation of double-strand breaks (DSBs), which usually take place in accessible chromatin with features of active transcription in multiple… read more here.
Keywords: meiotic dsb; dna polymerase; transcription; dsb ... See more keywords
Mutation analysis by whole exome sequencing of endometrial hyperplasia and carcinoma in one patient: Abnormalities of polymerase epsilon and the phosphatidylinositol‐3 kinase pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.13459
Abstract: In order to understand the role of gene mutations in endometrial carcinogenesis, whole exome sequencing via laser microdissection was performed in the normal endometrium, atypical endometrial hyperplasia and endometrial carcinoma in the same patient. A… read more here.
Keywords: exome sequencing; carcinoma; whole exome; endometrial hyperplasia ... See more keywords
PD-1 blockade in solid tumors with defects in polymerase epsilon.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-21-0521
Abstract: Missense mutations in the polymerase epsilon (POLE) gene have been reported to generate proofreading defects resulting in an ultramutated genome and sensitize tumors to checkpoint blockade immunotherapy. However, many POLE mutated tumors do not respond… read more here.
Keywords: polymerase epsilon; pole; solid tumors; tumors defects ... See more keywords
Polymerase Epsilon-Associated Ultramutagenesis in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061467
Abstract: Simple Summary DNA polymerase epsilon is implicated to play a major role in DNA synthesis of the leading strand. In some cancer types, especially colorectal and endometrial cancers, polymerase epsilon is mutated at several hotspots,… read more here.
Keywords: mutation; tumor; cancer; polymerase epsilon ... See more keywords