Molecular signature of cardiac remodeling associated with Polymerase Gamma mutation.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2022.120469
Abstract: AIMS Metabolic function/dysfunction is central to aging biology. This is well illustrated by the Polymerase Gamma (POLG) mutant mouse where a key residue of the mitochondrial DNA polymerase is mutated (D257A), causing loss of mitochondrial… read more here.
Keywords: polg mutant; dysfunction; polymerase gamma; polymerase ... See more keywords
Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria.
Sign Up to like & getrecommendations! Published in 2017 at "Mitochondrion"
DOI: 10.1016/j.mito.2016.11.001
Abstract: Human mitochondrial DNA (mtDNA) is replicated by the mitochondrial DNA polymerase gamma (POLG). Using proximity dependent biotin labelling (BioID), we characterized the POLG interactome and identified new interaction partners involved in mtDNA maintenance, transcription, translation… read more here.
Keywords: dna; dna polymerase; polymerase gamma; ruvbl2 ... See more keywords
The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
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DOI: 10.1038/s41467-018-04895-1
Abstract: Double-strand breaks in the mitochondrial DNA (mtDNA) result in the formation of linear fragments that are rapidly degraded. However, the identity of the nuclease(s) performing this function is not known. We found that the exonuclease… read more here.
Keywords: dna; dna fragments; formation; polymerase gamma ... See more keywords
Polymerase gamma in bipolar disorder: It's complicated
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatry and Clinical Neurosciences"
DOI: 10.1111/pcn.12531
Abstract: B IPOLAR DISORDER (BD) CLUSTERS in families but does not follow a Mendelian pattern. Current data suggest that variable groups of genes of mildly disease-promoting or diseasepreventing properties combine to confer vulnerability or resilience to… read more here.
Keywords: respiratory chain; dna; epigenetic environmental; disorder ... See more keywords