Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
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DOI: 10.1038/s41467-019-12272-9
Abstract: DNA polymerase θ (Polθ) is a unique polymerase-helicase fusion protein that promotes microhomology-mediated end-joining (MMEJ) of DNA double-strand breaks (DSBs). How full-length human Polθ performs MMEJ at the molecular level remains unknown. Using a biochemical… read more here.
Keywords: end joining; polymerase helicase; pol; dna ... See more keywords