Pharmacokinetics, Food Effect, Ketoconazole Interaction, and Safety of JTK‐853, a Novel Nonnucleoside HCV Polymerase Inhibitor, After Ascending Single and Multiple Doses in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.656
Abstract: Pharmacokinetics, safety, and tolerability of JTK‐853, a novel HCV polymerase inhibitor, were evaluated in single and multiple ascending dose (SAD, MAD) studies, with food‐ and ketoconazole‐related effects on exposure to JTK‐853 and its active (CYP3A4… read more here.
Keywords: hcv polymerase; jtk 853; 853 novel; single multiple ... See more keywords
Kinetic degradation study for the first licenced anti-influenza polymerase inhibitor, baloxavir marboxil, using HPLC-MS.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200020
Abstract: The first licensed polymerase inhibitor, baloxavir marboxil was recently approved for the treatment of influenza A and B viruses. Furthermore, there is growing interest in testing the antiviral activity of baloxavir marboxil against Coronavirus. Despite… read more here.
Keywords: inhibitor baloxavir; degradation; polymerase inhibitor; baloxavir marboxil ... See more keywords
A guide to poly ADP-ribose polymerase inhibitor (PARPi) toxicity management
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2020-001631
Abstract: Ovarian cancer is the fifth most common cause of cancer-related death in women and is the leading cause of gynecologic-related deaths in the United States.[1 2][1] Only ~40% of patients with ovarian cancer achieve a… read more here.
Keywords: poly adp; guide poly; polymerase inhibitor; ribose polymerase ... See more keywords