RNA Polymerase Ribozyme That Recognizes the Template-Primer Complex through Tertiary Interactions.
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DOI: 10.1021/acs.biochem.3c00091
Abstract: RNA enzymes (ribozymes) often rely on specific base-pairing interactions to engage RNA substrates, which limits the substrate sequence generality of these enzymes. An RNA polymerase ribozyme that was previously optimized by directed evolution to operate… read more here.
Keywords: polymerase ribozyme; polymerase; template primer; ribozyme ... See more keywords
The NTP binding site of the polymerase ribozyme
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky898
Abstract: Abstract A previously developed RNA polymerase ribozyme uses nucleoside triphosphates (NTPs) to extend a primer 3′-terminus, templated by an RNA template with good fidelity, forming 3′-5′-phosphordiester bonds. Indirect evidence has suggested that the ribozyme's accessory… read more here.
Keywords: ntp binding; binding site; site; polymerase ribozyme ... See more keywords