Structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104971
Abstract: Influenza viruses can cause severe respiratory infections in humans, leading to nearly half a million deaths worldwide each year. Improved antiviral drugs are needed to address the threat of development of novel pandemic strains. Current… read more here.
Keywords: influenza polymerase; polymerase; terminal domain; polymerase subunit ... See more keywords
The RNA polymerase II subunit Rpb9 activates ATG1 transcription and autophagy
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202254993
Abstract: Macroautophagy/autophagy is a conserved process in eukaryotic cells that mediates the degradation and recycling of intracellular substrates. Proteins encoded by autophagy‐related (ATG) genes are essentially involved in the autophagy process and must be tightly regulated… read more here.
Keywords: rpb9; transcription; rna polymerase; polymerase subunit ... See more keywords