Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c02101
Abstract: Synthetic lethality (SL) is an innovative strategy in targeted anticancer therapy that exploits tumor genetic vulnerabilities. This topic has come to the forefront in recent years, as witnessed by the increased number of publications since… read more here.
Keywords: polymerase; dna polymerase; polymerase theta; therapy ... See more keywords
Abstract A107: Development of polymerase theta inhibitors for precision medicine in BRCA-deficient cancers
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DOI: 10.1158/1535-7163.targ-17-a107
Abstract: DNA polymerase theta (Polq) is important for the proliferation of BRCA-deficient cancer cells, but is dispensable for normal cell growth. Thus, Polq is widely considered to be an important new drug target for BRCA-deficient cancers,… read more here.
Keywords: medicine; brca deficient; polymerase theta; deficient cancers ... See more keywords
DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage.
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DOI: 10.1182/blood.2022018428
Abstract: Leukemia cells accumulate DNA damage but altered DNA repair mechanisms protect them from apoptosis. We showed here that formaldehyde generated by serine/one-carbon cycle metabolism contributed to accumulation of toxic DNA-protein crosslinks (DPCs) in leukemia cells,… read more here.
Keywords: leukemia cells; dna; dna polymerase; dna damage ... See more keywords