Design of Polymeric Gene Carriers for Effective Intracellular Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2018.02.006
Abstract: Polymeric carriers have emerged as major non-viral alternatives for gene delivery due to their lower immunogenicity and pathogenicity. However, during intracellular delivery of these carriers, multiple barriers have to be overcome or the efficiency of… read more here.
Keywords: delivery; polymeric gene; design polymeric; gene delivery ... See more keywords
Synthetic Helical Polypeptide as a Gene Transfection Enhancer.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00331
Abstract: The relatively low transfection efficiency limits further application of polymeric gene carriers. It is imperative to exploit a universal and simple strategy to enhance the gene transfection efficiency of polymeric gene carriers. Herein, we prepared… read more here.
Keywords: polymeric gene; gene transfection; transfection efficiency; gene ... See more keywords
Tempo-spatial Activation of Sequential Quadruple Stimuli for High Gene Expression of Polymeric Gene Nanocomplexes.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.6b01065
Abstract: The clinical application of intracellular gene delivery via nanosized carriers is hindered by intracellular multistep barriers that limit high levels of gene expression. To solve these issues, four different intracellular or external stimuli that can… read more here.
Keywords: polymeric gene; gene expression; pha; activation ... See more keywords