Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105373
Abstract: Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not… read more here.
Keywords: based varieties; polymeric nanocarriers; drug delivery; physicochemical properties ... See more keywords
Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in glioma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03365-y
Abstract: Background and purpose Glioblastoma multiforme (GBM) is the most aggressive subtype of malignant gliomas, with an average survival rate of 15 months after diagnosis. More than 90% of all GBMs have activating mutations in the MAPK/ERK… read more here.
Keywords: delivered via; binimetinib mek162; polymeric nanocarriers; mek162 delivered ... See more keywords
Reactive oxygen species-sensitive polymeric nanocarriers for synergistic cancer therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.05.023
Abstract: Reactive oxygen species (ROS)-responsive nanocarriers have aroused widespread interest in recent years. On the one hand, a high ROS level has been detected in many types of tumor cells. On the other hand, ROS generation… read more here.
Keywords: reactive oxygen; sensitive polymeric; oxygen species; polymeric nanocarriers ... See more keywords
Current applications and benefits of polymeric nanocarriers for management of skin disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220525141021
Abstract: Preparations for topical application are highly important for therapeutic and cosmetic use since the skin has an extensive and accessible application area. Among the many advantages, this route avoids the systemic effects of the substances,… read more here.
Keywords: skin; nanotechnology; current applications; polymeric nanocarriers ... See more keywords
Polymeric Nanocarriers: A New Horizon for the Effective Management of Breast Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666170829164828
Abstract: BACKGROUND Delivery of chemotherapeutic drugs for the diagnosis and treatment of cancer is becoming advanced day by day. However, the challenge of the effective delivery system still does exist. In various types of cancers, breast… read more here.
Keywords: nanocarriers new; new horizon; polymeric nanocarriers; breast cancer ... See more keywords
Advancements in Polymeric Nanocarriers to Mediate Targeted Therapy against Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112432
Abstract: Triple-negative breast cancer (TNBC) is a destructive disease with a poor prognosis, low survival rate and high rate of metastasis. It comprises 15% of total breast cancers and is marked by deficiency of three important… read more here.
Keywords: breast; triple negative; polymeric nanocarriers; breast cancer ... See more keywords
Non-spherical Polymeric Nanocarriers for Therapeutics: The Effect of Shape on Biological Systems and Drug Delivery Properties
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010032
Abstract: This review aims to highlight the importance of particle shape in the design of polymeric nanocarriers for drug delivery systems, along with their size, surface chemistry, density, and rigidity. Current manufacturing methods used to obtain… read more here.
Keywords: polymeric nanocarriers; non spherical; drug delivery; shape ... See more keywords
Insights on Development Aspects of Polymeric Nanocarriers: The Translation from Bench to Clinic
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14173545
Abstract: Scientists are focusing immense attention on polymeric nanocarriers as a prominent delivery vehicle for several biomedical applications including diagnosis of diseases, delivery of therapeutic agents, peptides, proteins, genes, siRNA, and vaccines due to their exciting… read more here.
Keywords: development aspects; polymeric nanocarriers; insights development; delivery ... See more keywords
Biodegradable polymeric nanocarriers for oral delivery of antiretroviral drug: Pharmacokinetic and in vitro permeability studies
Sign Up to like & getrecommendations! Published in 2021 at "journal of applied pharmaceutical science"
DOI: 10.7324/japs.2021.110405
Abstract: The current work aimed to formulate Darunavir (DRV) loaded poly (ɛ-caprolactone) nanoparticles (NPs) to address the issue of low bioavailability. NPs were formulated by employing D-α Tocopherol Polyethylene Glycol Succinate 1,000 (TPGS) as stabilizer using… read more here.
Keywords: nanocarriers oral; drv; drug; delivery ... See more keywords