PET-CT Imaging of Polymeric Nanoparticle Tumor Accumulation in Patients.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202201043
Abstract: Several FDA/EMA-approved nanomedicines have demonstrated improved pharmacokinetics and toxicity profiles compared to their conventional chemotherapeutic counterparts. The next step to increase therapeutic efficacy depends on tumor accumulation, which can be highly heterogeneous. A clinical tool… read more here.
Keywords: accumulation; pet imaging; tumor accumulation; polymeric nanoparticle ... See more keywords
A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205475
Abstract: Messenger RNA (mRNA)‐based therapies offer enhanced control over the production of therapeutic proteins for many diseases. Their clinical implementation warrants formulations capable of delivering them safely and effectively to target sites. Owing to their chemical… read more here.
Keywords: nanoparticle formulation; delivery; mrna delivery; polymeric nanoparticle ... See more keywords
Analysis of polymeric nanoparticle properties for siRNA/DNA delivery in a tumor xenograft tissue slice air–liquid interface model
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200415
Abstract: Classical two‐dimensional (2D) cell culture as a drug or nanoparticle test system only poorly recapitulates in vivo conditions. Animal studies are costly, ethically controversial, and preclude large‐scale testing. read more here.
Keywords: nanoparticle; nanoparticle properties; analysis polymeric; properties sirna ... See more keywords
Polymeric Nanoparticle-Based Vaccine Adjuvants and Delivery Vehicles.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2020_226
Abstract: As vaccine formulations have progressed from including live or attenuated strains of pathogenic components for enhanced safety, developing new adjuvants to more effectively generate adaptive immune responses has become necessary. In this context, polymeric nanoparticles… read more here.
Keywords: adjuvants delivery; delivery vehicles; polymeric nanoparticle; delivery ... See more keywords
Polymeric nanoparticle-based nanovaccines for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Materials horizons"
DOI: 10.1039/d2mh01358d
Abstract: Therapeutic cancer vaccines, which are designed to amplify tumor-specific T cell responses, have been envisioned as one of the most powerful tools for effective cancer immunotherapy. However, increasing the potency, quality and durability of the… read more here.
Keywords: cancer vaccines; nanoparticle based; cancer; polymeric nanoparticle ... See more keywords
Optical anisotropy measurement of polymeric nanoparticle with polarization interferometric confocal microscope
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Crystals and Liquid Crystals"
DOI: 10.1080/15421406.2017.1358037
Abstract: ABSTRACT This study proposes a polarization Interferometric nonlinear confocal microscope to analyze a single nanoparticle for drug delivery system (DDS). The system includes the Michelson-type interferometer in a nonlinear confocal laser microscope. The microscope has… read more here.
Keywords: polymeric nanoparticle; polarization interferometric; confocal microscope; microscope ... See more keywords
Abstract LB440: PRV131 is an effective and safe polymeric nanoparticle suspension for intratumoral cisplatin delivery
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-lb440
Abstract: Background: Systemic administration of platinum-based chemotherapy often leads to dose-limiting toxicity, affecting quality of life. While intratumoral delivery may reduce or eliminate the systemic toxicities and adverse side effects associated with intravenous cisplatin chemotherapy, this… read more here.
Keywords: nanoparticle suspension; cisplatin; delivery; polymeric nanoparticle ... See more keywords