Tetrac-conjugated polymersomes for integrin-targeted delivery of camptothecin to colon adenocarcinoma in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.039
Abstract: In this study, we prepared tetraiodothyroacetic acid (tetrac) conjugated PEG-PLGA polymersomes for the targeted delivery of camptothecin to colon adenocarcinoma. Tetrac, which binds to integrin αvβ3 with high affinity and specificity, was covalently conjugated to… read more here.
Keywords: microscopy; camptothecin; integrin targeted; tetrac conjugated ... See more keywords
Extensive preclinical investigation of polymersomal formulation of doxorubicin versus Doxil‐mimic formulation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.08.030
Abstract: &NA; Due to the severe cardiotoxicity of doxorubicin, its usage is limited. This shortcoming could be overcome by modifying pharmacokinetics of the drugs via preparation of various nanoplatforms. Doxil, a well‐known FDA‐approved nanoplatform of doxorubicin… read more here.
Keywords: polymersomal formulation; doxil mimic; formulation; formulation doxorubicin ... See more keywords
Encapsulation of Thermo‐responsive Gel in pH‐sensitive Polymersomes as Dual‐Responsive Smart carriers for Controlled Release of Doxorubicin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.08.039
Abstract: ABSTRACT In the current study, thermoresponsive poly(N‐isopropylacrylamide)‐doxorubicin (PNIPAM‐DOX) hydrogel was synthesized and loaded into pH‐responsive poly ethylene glycol)‐2,4,6‐ trimethoxy benzylidene pentaerythritol carbonate (PEG‐PTMBPEC) polymersomes in order to fabricate a smart thermo‐pH stimuli responsive drug delivery… read more here.
Keywords: polymersomal formulation; thermo responsive; dox; release ... See more keywords