Systemic calcitonin gene-related peptide receptor antagonism decreases survival in a large animal model of polymicrobial sepsis: blinded randomised controlled laboratory trial.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2021.11.042
Abstract: BACKGROUND Calcitonin gene-related peptide (CGRP) and procalcitonin, which are overexpressed in sepsis, exert distinct immunomodulatory effects mediated through the CGRP receptor. The CGRP receptor antagonist olcegepant improves survival in murine sepsis. This study evaluated whether… read more here.
Keywords: receptor antagonism; sepsis; model polymicrobial; polymicrobial sepsis ... See more keywords
The Immunopathogenesis of Polymicrobial Sepsis.
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DOI: 10.1097/shk.0000000000002049
Abstract: ABSTRACT This report deals with the advances made in the areas of complement and its role in sepsis, both in mice and in humans. The study relates to work over the past 25 years (late… read more here.
Keywords: sepsis; polymicrobial sepsis; dysfunction; immunopathogenesis polymicrobial ... See more keywords
IM156, a new AMPK activator, protects against polymicrobial sepsis
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DOI: 10.1111/jcmm.17341
Abstract: IM156, a novel biguanide with higher potency of AMP‐activated protein kinase activation than metformin, has inhibitory activity against angiogenesis and cancer. In this study, we investigated effects of IM156 against polymicrobial sepsis. Administration of IM156… read more here.
Keywords: sepsis; activator protects; new ampk; ampk activator ... See more keywords
Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis
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DOI: 10.1126/scitranslmed.abo2028
Abstract: Sepsis is a challenging clinical syndrome caused by a dysregulated host response to infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 (ACOD1) in monocytes and macrophages. Previous studies have suggested that… read more here.
Keywords: sepsis; cdk2; aconitate decarboxylase; polymicrobial sepsis ... See more keywords
Time-serial expression of toll-like receptor 4 signaling during polymicrobial sepsis in rats
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DOI: 10.1177/03946320221090021
Abstract: Sepsis caused by aggressive infection is a severe clinical problem with an increasing incidence worldwide. Toll-like receptors and their common adapter myeloid differentiation factor 88 (MyD88) can activate immune responses by recognizing a foreign microbe’s… read more here.
Keywords: sepsis; time; toll like; serial expression ... See more keywords
αDβ2 as a novel target of experimental polymicrobial sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1059996
Abstract: Since sepsis was defined three decades ago, it has been a target of intensive study. However, there is no specific sepsis treatment available, with its high mortality and morbidity. αDβ2 (CD11d/CD18) is one of the… read more here.
Keywords: sepsis; target experimental; experimental polymicrobial; polymicrobial sepsis ... See more keywords
ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1089905
Abstract: Polymicrobial sepsis still has a high mortality rate despite the development of antimicrobial agents, elaborate strategies to protect major organs, and the investment of numerous medical resources. Mitochondrial dysfunction, which acts as the center of… read more here.
Keywords: sepsis; zln005 improves; improves survival; sepsis increasing ... See more keywords
Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis
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DOI: 10.3390/ijms19103163
Abstract: Liver dysfunction during sepsis is an independent risk factor leading to increased mortality rates. Specifically, dysregulation of hepatic biotransformation capacity, especially of the cytochrome P450 (CYP) system, represents an important distress factor during host response.… read more here.
Keywords: sepsis; ceramide content; expression; polymicrobial sepsis ... See more keywords
Molecular Methodologies for Improved Polymicrobial Sepsis Diagnosis
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DOI: 10.3390/ijms23094484
Abstract: Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis. Routinely used culture-dependent microbiological diagnostic techniques have low sensitivity, often leading to missed identification of all causative organisms. To overcome these limitations, culture-independent methods… read more here.
Keywords: sepsis; methodologies improved; pathogen; improved polymicrobial ... See more keywords