Polymorphic forms of bisoprolol fumarate
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DOI: 10.1007/s10973-018-7553-8
Abstract: Bisoprolol fumarate is a beta blocker-type drug substance which has been well known for several decades. However, no relevant data can be found in the literature about its crystal polymorphism. The purpose of this paper… read more here.
Keywords: form form; polymorphic forms; bisoprolol fumarate; form ... See more keywords
Molecular, Solid-State and Surface Structures of the Conformational Polymorphic Forms of Ritonavir in Relation to their Physicochemical Properties
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Research"
DOI: 10.1007/s11095-021-03048-2
Abstract: Purpose Application of multi-scale modelling workflows to characterise polymorphism in ritonavir with regard to its stability, bioavailability and processing. Methods Molecular conformation, polarizability and stability are examined using quantum mechanics (QM). Intermolecular synthons, hydrogen bonding,… read more here.
Keywords: solid state; polymorphic forms; surface; state surface ... See more keywords
New Insights into the Crystallographic Disorder in the Polymorphic Forms of Aspirin from Low-Frequency Vibrational Analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00727
Abstract: Terahertz time-domain spectroscopy (THz-TDS) is applied to two polymorphs of acetylsalicylic acid (aspirin), and the experimental spectra are compared to lattice dynamical calculations using high accuracy density functional theory. The calculations confirm that forms I… read more here.
Keywords: disorder; thz tds; frequency vibrational; polymorphic forms ... See more keywords
Quantum Chemical Study on Mefenamic Acid Polymorphic Forms
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DOI: 10.1021/acsomega.1c06967
Abstract: Three polymorphic structures of mefenamic acid, which is a very popular drug, have been studied using quantum chemical methods. It has been shown that the centrosymmetric dimer formed due to two O–H···O hydrogen bonds is… read more here.
Keywords: structure; polymorphic forms; energy; mefenamic acid ... See more keywords
The structural pathway from its solvated molecular state to the solution crystallisation of the α- and β-polymorphic forms of para amino benzoic acid.
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DOI: 10.1039/d1fd00112d
Abstract: Para amino benzoic acid (PABA) has two well-characterised α- and β-polymorphic forms and, whilst both crystallise in the monoclinic space group P21/n, they have quite different crystal chemistry and crystallisability behaviour. Previous work has shown… read more here.
Keywords: crystallisation; state; polymorphic forms; form ... See more keywords
Structural Specificity of Polymorphic Forms of α-Synuclein Amyloid
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051324
Abstract: The structural transformation producing amyloids is a phenomenon that sheds new light on the protein folding problem. The analysis of the polymorphic structures of the α-synuclein amyloid available in the PDB database allows analysis of… read more here.
Keywords: polymorphic forms; synuclein amyloid; specificity polymorphic; micelle like ... See more keywords