Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119902
Abstract: In this paper, we present a kinetic investigation of the polymorphic transformation γ→α of sorbitol under milling in the objective to identify the microscopic mechanisms that govern this type of solid-state transformation. The milling was… read more here.
Keywords: milling; mechanism; transformation; transformation sorbitol ... See more keywords
Exploring the influence factors and improvement strategies of drug polymorphic transformation combined kinetic and thermodynamic perspectives during the formation of nanosuspensions.
Sign Up to like & getrecommendations! Published in 2022 at "Drug development and industrial pharmacy"
DOI: 10.1080/03639045.2022.2061988
Abstract: Nanosuspensions can effectively increase saturation solubility and improve the bioavailability of poorly water-soluble drugs attributed to high loading and surface-to-volume ratio. Wet media milling has been regarded as a scalable method to prepare nanosuspensions because… read more here.
Keywords: improvement strategies; influence factors; polymorphic transformation; transformation ... See more keywords
Amorphization and a Polymorphic Transformation of Boron Stimulated by High Dynamic Pressures
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DOI: 10.1134/s002136401818008x
Abstract: Structural transformations of polycrystalline boron have been studied under megabar multiple-shock compression. Shock-wave experiments on the compression and subsequent recovery of polycrystalline samples of β-rhombohedral boron β-B106 have been performed. Thermodynamic states of boron under… read more here.
Keywords: transformation boron; amorphization polymorphic; transformation; boron stimulated ... See more keywords
Evaluation of Thermal-Induced Polymorphic Transformation on Desloratadine and Desloratadine-Benzoic Acid Salt
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DOI: 10.34172/ps.2020.59
Abstract: Background: Active pharmaceutical ingredients face a challenge in manufacturing due to adverse physicomechanical properties. Desloratadine (DES) form I exhibits poor mechanical behavior through the formation of capping during the tableting process. Salt formation from DES… read more here.
Keywords: polymorphic transformation; desloratadine; des des; transformation ... See more keywords