Polymorphisms of the cytidine deaminase APOBEC3F have different HIV-1 restriction efficiencies.
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DOI: 10.1016/j.virol.2018.11.004
Abstract: The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein… read more here.
Keywords: restriction; apobec3f 108; hiv; vif ... See more keywords