Effects of CYP2C19 and CYP3A5 genetic polymorphisms on the pharmacokinetics of cilostazol and its active metabolites
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DOI: 10.1007/s00228-018-2522-5
Abstract: PurposeCYP3A4, CYP2C19, and CYP3A5 are primarily involved in the metabolism of cilostazol. We investigated the effects of CYP2C19 and CYP3A5 genetic polymorphisms on the pharmacokinetics of cilostazol and its two active metabolites.MethodsThirty-three healthy Korean volunteers… read more here.
Keywords: polymorphisms pharmacokinetics; cyp2c19 cyp3a5; active metabolites; cyp3a5 genetic ... See more keywords
Effects of CYP2C19 genetic polymorphisms on the pharmacokinetics of lacosamide in Korean patients with epilepsy
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DOI: 10.1111/epi.17399
Abstract: Many pharmacokinetic studies of lacosamide (LCM) have been reported, but no large‐scale clinical study has been conducted on genetic polymorphisms that affect the metabolism of LCM. Therefore, we designed a pharmacogenetic study of LCM to… read more here.
Keywords: pharmacokinetics lacosamide; genetic polymorphisms; cyp2c19 genetic; polymorphisms pharmacokinetics ... See more keywords
Association between Food/UGT2B7 Polymorphisms and Pharmacokinetics/Pharmacodynamics Properties of Indapamide in Healthy Humans
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DOI: 10.3390/biomedicines11051501
Abstract: Indapamide is an effective and safe antihypertensive medication showing a beneficial effect in combination with other antihypertensive agents regarding morbidity and mortality. A comparative study was performed under fasting and fed conditions to investigate the… read more here.
Keywords: pharmacokinetics pharmacodynamics; food; polymorphisms pharmacokinetics; association food ... See more keywords