Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway-mediated antioxidant response.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23344
Abstract: Polymyxin B (PMB) is a polypeptide antibiotic widely used in treating multidrug‐resistant Gram‐negative bacteria. However, nephrotoxicity is a serious adverse effect that limits its clinical use. Therefore, clarification of the molecular mechanism of PMB‐induced renal… read more here.
Keywords: nrf2 nqo1; nqo1 pathway; pmb; pmb induced ... See more keywords
New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21494
Abstract: Polymyxin B and colistin (polymyxin E) are bactericidal pentacationic lipopeptides that act specifically on Gram‐negative bacteria, first by disrupting their outermost permeability barrier, the outer membrane (OM), and then damaging the cytoplasmic membrane. The discovery… read more here.
Keywords: animal infection; infection; polymyxin; infection models ... See more keywords
Possible protective role of silybin against polymyxin E‐induced toxic effect in rat kidneys: A biochemical approach
Sign Up to like & getrecommendations! Published in 2017 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23249
Abstract: Polymyxin E was used for treating gram‐negative bacterial infections but not recently for fear of its nephrotoxicity. Silybin has potential to counteract nephrotoxicity; however, few studies have investigated its protective effect on the kidney in… read more here.
Keywords: effect; protective role; polymyxin; possible protective ... See more keywords
Recent progress on elucidating the molecular mechanism of plasmid-mediated colistin resistance and drug design
Sign Up to like & getrecommendations! Published in 2019 at "International Microbiology"
DOI: 10.1007/s10123-019-00112-1
Abstract: Antibiotic resistance is a growing global challenge to public health. Polymyxin is considered to be the last-resort antibiotic against most gram-negative bacteria. Recently, discoveries of a plasmid-mediated, transferable mobilized polymyxin resistance gene ( mcr-1 )… read more here.
Keywords: mechanism; drug design; drug; plasmid mediated ... See more keywords
Colistin and polymyxin B for treatment of nosocomial infections in intensive care unit patients: pharmacoeconomic analysis
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-018-0766-x
Abstract: Background The emergence and rapid spread of multidrug-resistant gram-negative bacteria related to nosocomial infections is a growing worldwide problem, and polymyxins have become important due to the lack of new antibiotics. Objectives To evaluate the… read more here.
Keywords: nosocomial infections; treatment; intensive care; polymyxin ... See more keywords
Polymyxin for the treatment of intracranial infections of extensively drug-resistant bacteria in children after neurosurgical operation
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DOI: 10.1007/s12519-020-00350-8
Abstract: Background Increased meningitis caused by extensively drug-resistant bacillary presents a significant challenge in antibiotic selection. The aim of our study was to evaluate the efficacy and safety of polymyxin in the treatment of post-neurosurgical meningitis due… read more here.
Keywords: meningitis; drug; extensively drug; drug resistant ... See more keywords
Development of dilipid polymyxins: Investigation on the effect of hydrophobicity through its fatty acyl component.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.07.018
Abstract: Continuous development of new antibacterial agents is necessary to counter the problem of antimicrobial resistance. Polymyxins are considered as drugs of last resort to combat multidrug-resistant Gram-negative pathogens. Structural optimization of polymyxins requires an in-depth… read more here.
Keywords: component; dilipid polymyxins; polymyxin; effect hydrophobicity ... See more keywords
Polysorbate 80 and polymyxin B inhibit Stenotrophomonas maltophilia biofilm.
Sign Up to like & getrecommendations! Published in 2017 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2016.11.008
Abstract: Stenotrophomonas maltophilia is an opportunistic multiple-drug-resistant human pathogen that forms biofilms on implanted medical devices. We examined the potential inhibitory activity of polysorbate 80 and polymyxin B against S. maltophilia. A combination of subMIC polymyxin… read more here.
Keywords: polysorbate polymyxin; polymyxin; polymyxin inhibit; stenotrophomonas maltophilia ... See more keywords
Effect of increasing meropenem MIC on the killing activity of meropenem in combination with amikacin or polymyxin B against MBL- and KPC-producing Enterobacter cloacae.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.06.013
Abstract: Carbapenem resistant Enterobacteriaceae (CRE) are a growing threat worldwide. Infections caused by these organisms have exhibited high rates of mortality (50%) for which there is no standard of care and a dearth of clinical trials.… read more here.
Keywords: producing enterobacter; meropenem; polymyxin; enterobacter cloacae ... See more keywords
Synergistic effect between nisin and polymyxin B against pandrug-resistant and extensively drug-resistant Acinetobacter baumannii.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.03.009
Abstract: Acinetobacter baumannii is an opportunistic pathogen predominantly associated with nosocomial infections. The World Health Organization's data on antibiotic-resistant 'priority pathogens' reports carbapenem-resistant A. baumannii as a pathogen which is in critical need of research and… read more here.
Keywords: nisin polymyxin; drug; polymyxin; acinetobacter ... See more keywords
Polymyxin resistance in Carbapenem-resistant Enterobacteriaceae isolates from patients without polymyxin exposure ‒ a multicenter study in China.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106262
Abstract: OBJECTIVES Polymyxin was recently approved for the clinical treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections in China. The aim of this study is to explore the prevalence and molecular mechanisms of polymyxin resistant CRE (PR-CRE) prior… read more here.
Keywords: exposure; study; polymyxin resistance; polymyxin ... See more keywords