Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00300
Abstract: Neurotoxicity is one major unwanted side-effects associated with polymyxin (i.e., colistin and polymyxin B) therapy. Clinically, colistin neurotoxicity is characterized by neurological symptoms including dizziness, visual disturbances, vertigo, confusion, hallucinations, seizures, ataxia, and facial and… read more here.
Keywords: polymyxin induced; induced neurotoxicity; neurotoxicity; polymyxin ... See more keywords
Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01254-17
Abstract: ABSTRACT Polymyxins are a last line of defense against multidrug-resistant Gram-negative pathogens. Recent pharmacological data show that intravenous polymyxins can cause nephrotoxicity in up to 60% of patients, and the plasma concentrations of polymyxins achieved… read more here.
Keywords: polymyxin induced; induced nephrotoxicity; methionine; mitochondrial superoxide ... See more keywords
Proteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02730-21
Abstract: Polymyxin B-induced skin hyperpigmentation seriously affects the psychological health and compliance of patients. This study provides a proteomic clue to the mechanism at the cellular level for understanding polymyxin B-induced hyperpigmentation, contributing to a follow-up… read more here.
Keywords: mechanism; signaling pathways; polymyxin induced; hyperpigmentation ... See more keywords
Polymyxin B-Induced Skin Hyperpigmentation
Sign Up to like & getrecommendations! Published in 2020 at "Case Reports in Medicine"
DOI: 10.1155/2020/6461329
Abstract: Polymyxin B-induced skin hyperpigmentation is a rare adverse drug reaction (ADR). In this report, we present the case of a patient who underwent an abscess resection with right epididymitis, in which a multidrug-resistant Klebsiella pneumoniae… read more here.
Keywords: polymyxin induced; medicine; skin hyperpigmentation; induced skin ... See more keywords
Prevalence of polymyxin-induced nephrotoxicity and its predictors in critically ill adult patients: A meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v10.i31.11466
Abstract: BACKGROUND Polymyxin-induced nephrotoxicity is a major safety concern in clinical practice due to long-term adverse outcomes and high mortality. AIM To conducted a systematic review and meta-analysis of the prevalence and potential predictors of polymyxin-induced… read more here.
Keywords: prevalence; analysis; polymyxin induced; nephrotoxicity ... See more keywords
Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11030307
Abstract: Inhaled polymyxins are increasingly used to treat pulmonary infections caused by multidrug-resistant Gram-negative pathogens. We have previously shown that apoptotic pathways, autophagy and oxidative stress are involved in polymyxin-induced toxicity in human lung epithelial cells.… read more here.
Keywords: human lung; polymyxin induced; toxicity; lung epithelial ... See more keywords