Polymyxin resistance in Carbapenem-resistant Enterobacteriaceae isolates from patients without polymyxin exposure ‒ a multicenter study in China.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106262
Abstract: OBJECTIVES Polymyxin was recently approved for the clinical treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections in China. The aim of this study is to explore the prevalence and molecular mechanisms of polymyxin resistant CRE (PR-CRE) prior… read more here.
Keywords: exposure; study; polymyxin resistance; polymyxin ... See more keywords
Impact of the cAMP-cAMP Receptor Protein Regulatory Complex on Lipopolysaccharide Modifications and Polymyxin B Resistance in Escherichia coli
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bacteriology"
DOI: 10.1128/jb.00067-23
Abstract: Gram-negative bacteria can alter the structure of their LPS to promote resistance to cationic antimicrobial peptides, including polymyxin antibiotics. Polymyxins are considered last-resort antibiotics for treatment against multidrug-resistant Gram-negative organisms. Here, we explore how changes… read more here.
Keywords: camp; resistance; polymyxin resistance; gram negative ... See more keywords
Discovery and Characterization of Polymyxin-Resistance Genes pmrE and pmrF from Sediment and Seawater Microbiome
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02736-22
Abstract: Polymyxins are one of the last-resort antibiotics. Polymyxin resistance is a severe threat to combat multidrug-resistant pathogens. ABSTRACT Polymyxins are the last-line antibiotics used to treat Gram-negative pathogens. Thus, the discovery and biochemical characterization of… read more here.
Keywords: polymyxin resistance; resistance; pmre pmrf; resistance genes ... See more keywords
Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance.
Sign Up to like & getrecommendations! Published in 2018 at "Canadian journal of microbiology"
DOI: 10.1139/cjm-2017-0475
Abstract: Enterobacter cloacae strain R11 is a multidrug-resistant bacterium isolated from sewage water near a swine feedlot in China. Strain R11 can survive in medium containing up to 192 μg/mL polymyxin E, indicating a tolerance for… read more here.
Keywords: polymyxin resistance; complete genome; resistance; polymyxin ... See more keywords
Overview of polymyxin resistance in Enterobacteriaceae
Sign Up to like & getrecommendations! Published in 2022 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0349-2021
Abstract: ABSTRACT Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed… read more here.
Keywords: resistance enterobacteriaceae; overview polymyxin; resistance; polymyxin resistance ... See more keywords