Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa
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DOI: 10.1128/aac.01587-19
Abstract: In the present study, we employed untargeted metabolomics to investigate the synergistic killing mechanism of polymyxin B in combination with an aminoglycoside, amikacin, against a polymyxin-susceptible isolate of Pseudomonas aeruginosa, FADDI-PA111 (MIC = 2 mg/liter for… read more here.
Keywords: amikacin polymyxin; combination; polymyxin susceptible; polymyxin ... See more keywords
Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae
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DOI: 10.1128/msphere.00537-22
Abstract: OMVs can help bacteria to fight antibiotics not only by spreading antibiotic resistance genes but also by acting as protective armor against antibiotics. By employing proteomics, we found that OMVs have a potential role in… read more here.
Keywords: pneumoniae; polymyxin susceptible; outer membrane; resistance ... See more keywords
Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Klebsiella pneumoniae Clinical Isolates
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DOI: 10.3390/ijms19082356
Abstract: Gram-negative bacteria produce outer membrane vesicles (OMVs) as delivery vehicles for nefarious bacterial cargo such as virulence factors, which are antibiotic resistance determinants. This study aimed to investigate the impact of polymyxin B treatment on… read more here.
Keywords: paired polymyxin; polymyxin susceptible; pneumoniae; outer membrane ... See more keywords