Polynucleotide kinase-phosphatase (PNKP) mutations and neurologic disease
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2016.04.009
Abstract: A variety of human neurologic diseases are caused by inherited defects in DNA repair. In many cases, these syndromes almost exclusively impact the nervous system, underscoring the critical requirement for genome stability in this tissue.… read more here.
Keywords: kinase phosphatase; pnkp; polynucleotide kinase; pnkp mutations ... See more keywords
Single-Molecule Detection of Polynucleotide Kinase Based on Phosphorylation-Directed Recovery of Fluorescence Quenched by Au Nanoparticles.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b01783
Abstract: 5'-Polynucleotide kinase such as T4 polynucleotide kinase (T4 PNK) may catalyze the phosphorylation of 5'-hydroxyl termini in nucleic acids, playing a crucial role in DNA replication, DNA recombination, and DNA damage repair. Here, we demonstrate… read more here.
Keywords: detection; single molecule; fluorescence; polynucleotide kinase ... See more keywords
TiO2/g-C3N4/CdS Nanocomposite-Based Photoelectrochemical Biosensor for Ultrasensitive Evaluation of T4 Polynucleotide Kinase Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b04823
Abstract: Herein, an efficient photoelectrochemical (PEC) platform was constructed by a cosensitization strategy with a cascade energy level arrangement for the ultrasensitive evaluation of T4 polynucleotide kinase (T4 PNK). Based on CdSe quantum dots (QDs) with… read more here.
Keywords: polynucleotide kinase; c3n4 cds; tio2 c3n4; evaluation polynucleotide ... See more keywords
An Autocatalytic DNA Circuit Based on Hybridization Chain Assembly for Intracellular Imaging of Polynucleotide Kinase.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c08523
Abstract: Polynucleotide kinase (PNK) plays an essential role in various cellular events by regulating phosphorylation processes, and abnormal homeostasis of PNK could cause many human diseases. Herein, we proposed an autocatalytic hybridization system (AHS) through the… read more here.
Keywords: hybridization chain; dna; pnk; module ... See more keywords
A sensitive electrochemical assay for T4 polynucleotide kinase activity based on titanium dioxide nanotubes and a rolling circle amplification strategy
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra07745b
Abstract: An ultrasensitive electrochemical biosensor was developed for detection of T4 polynucleotide kinase (T4 PNK) activity based on titanium dioxide nanotubes (TiO2 NTs) and a rolling circle amplification (RCA) strategy. In this study, the immobilized T4… read more here.
Keywords: based titanium; polynucleotide kinase; activity based; strategy ... See more keywords