Multifunctional agents based on benzoxazolone as promising therapeutic drugs for diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113269
Abstract: Diabetic nephropathy (DN) is resulted from activations of polyol pathway and oxidative stress by abnormal metabolism of glucose, and no specific medication is available. We designed a novel class of benzoxazolone derivatives, and a number… read more here.
Keywords: polyol pathway; based benzoxazolone; benzoxazolone; diabetic nephropathy ... See more keywords
Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13595
Abstract: Propofol, a widely used short‐acting intravenous sedative agent, has gradually gained attention due to the tumour‐suppressing role and non‐anaesthetic effect. Dysfunction of metabolic reprogramming has been recognised as a well‐documented factor for tumour progression. The… read more here.
Keywords: gastric cancer; cell proliferation; mediated polyol; polyol pathway ... See more keywords
Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9020160
Abstract: Prolonged hyperglycemia is one of the main causes of reactive oxygen species and free radicals generation in diabetes which may affect various organs, including the eye. Oxidative damage to proteins and lipids in the eye… read more here.
Keywords: polyol pathway; chrysin; stress; diabetic rats ... See more keywords
The Synergistic Effects of Polyol Pathway-Induced Oxidative and Osmotic Stress in the Aetiology of Diabetic Cataracts
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25169042
Abstract: Cataracts are the world’s leading cause of blindness, and diabetes is the second leading risk factor for cataracts after old age. Despite this, no preventative treatment exists for cataracts. The altered metabolism of excess glucose… read more here.
Keywords: diabetic cataracts; stress; effects polyol; synergistic effects ... See more keywords
Physiological and Pathological Roles of Aldose Reductase
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DOI: 10.3390/metabo11100655
Abstract: Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway represents a minor route of glucose metabolism that… read more here.
Keywords: polyol pathway; physiological pathological; aldose reductase; pathological roles ... See more keywords
Recent Progress on Fructose Metabolism—Chrebp, Fructolysis, and Polyol Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15071778
Abstract: Excess fructose intake is associated with obesity, fatty liver, tooth decay, cancer, and cardiovascular diseases. Even after the ingestion of fructose, fructose concentration in the portal blood is never high; fructose is further metabolized in… read more here.
Keywords: fructose metabolism; metabolism; polyol pathway; chrebp fructolysis ... See more keywords