Antivirals against human polyomaviruses: Leaving no stone unturned.
Sign Up to like & getrecommendations! Published in 2021 at "Reviews in medical virology"
DOI: 10.1002/rmv.2220
Abstract: Human polyomaviruses (HPyVs) encompass more than 10 species infecting 30%-90% of the human population without significant illness. Proven HPyV diseases with documented histopathology affect primarily immunocompromised hosts with manifestations in brain, skin and renourinary tract… read more here.
Keywords: stone unturned; polyomaviruses leaving; leaving stone; polyomavirus associated ... See more keywords
Levels of donor‐derived cell‐free DNA and chemokines in BK polyomavirus‐associated nephropathy
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DOI: 10.1111/ctr.14785
Abstract: BK polyomavirus‐associated nephropathy (BKPyVAN) carries a risk of irreversible allograft injury. While detection of BK viremia and biopsy assessment are the current diagnostic gold standard, the diagnostic value of biomarkers reflecting tissue injury (donor‐derived cell‐free… read more here.
Keywords: polyomavirus associated; derived cell; cell free; donor derived ... See more keywords
Granulomatous inflammation in BK polyomavirus–associated nephropathy
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DOI: 10.1111/tid.12939
Abstract: Evolving BK polyomavirus–associated nephropathy (BKPyVAN) is characterized by tubulointerstitial inflammation that closely resembles acute T‐cell–mediated allograft rejection if tubulitis is significant. The cellular composition of the inflammation varies during the course of BKPyVAN, and clusters… read more here.
Keywords: associated nephropathy; granulomatous inflammation; inflammation; polyomavirus associated ... See more keywords
Low‐dose cidofovir and conversion to mTOR‐based immunosuppression in polyomavirus‐associated nephropathy
Sign Up to like & getrecommendations! Published in 2019 at "Transplant Infectious Disease"
DOI: 10.1111/tid.13228
Abstract: Polyomavirus‐associated nephropathy (PVAN) remains a relevant complication following kidney transplantation with allograft loss rates of up to 50%. Reduction in overall immunosuppression is a cornerstone of therapy, whereas no specific antiviral regimen has shown conclusive… read more here.
Keywords: associated nephropathy; low dose; dose cidofovir; polyomavirus associated ... See more keywords
An application of the 2018 Banff Classification for BK polyomavirus‐associated nephropathy in renal transplantation
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DOI: 10.1111/tid.13557
Abstract: There is still a lack of a recognized morphological classification of BK viral nephropathy (BKVN) which can better reflect the clinical manifestations and prognosis. read more here.
Keywords: banff classification; 2018 banff; classification; application 2018 ... See more keywords
JC polyomavirus-associated nephropathy in a kidney transplant recipient
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DOI: 10.1136/bcr-2025-268414
Abstract: This report describes a man in his late 50s who underwent donation-after-circulatory-death kidney transplantation in 2012, due to end-stage kidney disease of unknown origin. More than a decade post-transplant, he presented with a progressive decline… read more here.
Keywords: polyomavirus; polyomavirus associated; kidney transplant; associated nephropathy ... See more keywords
Clinical Relevance of Absolute BK Polyoma Viral Load Kinetics in Patients With Biopsy Proven BK Polyomavirus Associated Nephropathy
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DOI: 10.3389/fmed.2021.791087
Abstract: Introduction: The absolute BK viral load is an important diagnostic surrogate for BK polyomavirus associated nephropathy (PyVAN) after renal transplant (KTX) and serial assessment of BK viremia is recommended. However, there is no data indicating… read more here.
Keywords: viral load; polyomavirus associated; load; load kinetics ... See more keywords
Cell-Free Mitochondrial DNA: An Upcoming Non-Invasive Tool for Diagnosis of BK Polyomavirus-Associated Nephropathy
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DOI: 10.3390/biom14030348
Abstract: Mitochondria are essential organelles that possess their own DNA. Mitochondrial dysfunction has been revealed in many kidney diseases, including BK polyomavirus-associated nephropathy (BKPyVAN). In this study, we introduce an innovative approach for non-invasive monitoring of… read more here.
Keywords: diagnosis; cell free; polyomavirus associated; free mitochondrial ... See more keywords
BK Polyomavirus-Associated Nephropathy and Hemorrhagic Cystitis in Transplant Recipients—What We Understand and What Remains Unclear
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DOI: 10.3390/v17091256
Abstract: The reactivation of BK polyomavirus (BKPyV) during severe immunosuppression plays a crucial role in two significant syndromes observed in transplant recipients: BK polyomavirus-associated nephropathy (BKPyVAN) in kidney transplant patients and BK polyomavirus-associated hemorrhagic cystitis (BKPyV-HC)… read more here.
Keywords: transplant recipients; hemorrhagic cystitis; transplant; polyomavirus associated ... See more keywords