Oncostatin M Counteracts the Fibrotic Effects of TGF-β1 and IL-4 on Nasal-Polyp-Derived Fibroblasts: A Control of Fibrosis in Chronic Rhinosinusitis with Nasal Polyps?
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DOI: 10.3390/ijms23116308
Abstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with inflammation and tissue remodeling including myofibroblasts differentiation and extracellular matrix (ECM) deposition mediated by TGF-β1 and IL-4. Oncostatin M (OSM) is a cytokine involved in fibrotic… read more here.
Keywords: nasal polyps; fibrosis; derived fibroblasts; nasal polyp ... See more keywords
Induction of apoptosis in nasal polyp-derived fibroblasts by bleomycin A5 in vitro.
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DOI: 10.3892/mmr.2018.8540
Abstract: The present study aimed to evaluate the pro-apoptotic effects of bleomycin A5 on nasal polyp‑derived fibroblasts (NPDFs) and the underlying molecular mechanisms. Nasal polyp tissue was acquired from 10 patients during surgery and NPDFs were isolated… read more here.
Keywords: polyp derived; apoptosis; nasal polyp; induction apoptosis ... See more keywords