Encapsulating a Hydrophilic Chemotherapeutic into Rod-like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves its Efficacy.
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DOI: 10.1002/adfm.201605421
Abstract: Encapsulating hydrophilic chemotherapeutics into the core of polymeric nanoparticles can improve their therapeutic efficacy by increasing their plasma half-life, tumor accumulation and intracellular uptake, and by protecting them from premature degradation. To achieve these goals,… read more here.
Keywords: triblock polypeptide; hydrophilic chemotherapeutic; asymmetric triblock; polypeptide ... See more keywords
Expression of a novel dual-functional polypeptide and its pharmacological action research.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118890
Abstract: AIMS To develop a dual-functional medicine for hypoglycemic and anti-thrombus. MAIN METHODS The long-acting glucagon like peptide-1 (5×GLP-1) and nattokinase (NK) were cloned by SOE PCR and gained the GLP-1 and NK fusion polypeptide after… read more here.
Keywords: research; polypeptide; dual functional; thrombus ... See more keywords
Design of Polypeptides Self-Assembling into Antifouling Coatings: Exploiting Multivalency
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DOI: 10.1021/acs.biomac.2c00170
Abstract: We propose to exploit multivalent binding of solid-binding peptides (SBPs) for the physical attachment of antifouling polypeptide brushes on solid surfaces. Using a silica-binding peptide as a model SBP, we find that both tandem-repeated SBPs… read more here.
Keywords: polypeptide; polypeptides self; design polypeptides; design ... See more keywords
Supramolecular Protein Stabilization with Zwitterionic Polypeptide-Cucurbit[7]uril Conjugates.
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DOI: 10.1021/acs.biomac.2c01319
Abstract: Protein aggregation is an obstacle for the development of new biopharmaceuticals, presenting challenges in shipping and storage of vital therapies. Though a variety of materials and methods have been explored, the need remains for a… read more here.
Keywords: cucurbit uril; aggregation; polypeptide; zwitterionic ... See more keywords
Rational Construction of Protein-Mimetic Nano-Switch Systems Based on Secondary Structure Transitions of Synthetic Polypeptides.
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DOI: 10.1021/jacs.3c01156
Abstract: The manipulation of the flexibility/rigidity of polymeric chains to control their function is commonly observed in natural macromolecules but largely unexplored in synthetic systems. Herein, we construct a series of protein-mimetic nano-switches consisting of a… read more here.
Keywords: polypeptide; nano; structure; protein mimetic ... See more keywords
Injectable Click Polypeptide Hydrogels via Tetrazine-Norbornene Chemistry for Localized Cisplatin Release
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DOI: 10.3390/polym12040884
Abstract: Injectable, covalently cross-linked hydrogels have been widely investigated in drug delivery systems due to their superior mechanical properties and long-term stability. Conventional covalently cross-linked hydrogels are formed by chemical reactions that may interfere with natural… read more here.
Keywords: click polypeptide; hydrogel; polypeptide; chemistry ... See more keywords