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   Articles with "polypeptide receptor" as a keyword



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Design of novel therapeutics targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) to aid weight loss

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recommendations! Published in 2023 at "Expert Opinion on Drug Discovery"

DOI: 10.1080/17460441.2023.2203911

Abstract: ABSTRACT Introduction With obesity rates growing globally, there is a paramount need for new obesity pharmacotherapies to tackle this pandemic. Areas covered This review focuses on the design of therapeutics that target the glucose-dependent insulinotropic… read more here.

Keywords: glucose dependent; insulinotropic polypeptide; dependent insulinotropic; gipr ... See more keywords
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Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice

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recommendations! Published in 2022 at "British Journal of Pharmacology"

DOI: 10.1111/bph.15894

Abstract: The incretin hormone, gastric inhibitory peptide/glucose‐dependent insulinotropic polypeptide (GIP), secreted by the enteroendocrine K‐cells in the proximal intestine, may regulate lipid metabolism and adiposity, but its exact role in these processes is unclear. read more here.

Keywords: dependent insulinotropic; insulinotropic polypeptide; polypeptide receptor; glucose dependent ... See more keywords
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Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences

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recommendations! Published in 2022 at "Pharmaceuticals"

DOI: 10.3390/ph16010061

Abstract: Imaging and radiotherapy targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) could potentially benefit the management of neuroendocrine neoplasms (NENs), complementing clinically established radiopharmaceuticals. The aim of this study was to evaluate a GIPR-targeting positron emission… read more here.

Keywords: glucose dependent; insulinotropic polypeptide; specificity; dependent insulinotropic ... See more keywords