AI‐Driven Identification of Exceptionally Efficacious Polypharmacological Compounds That Extend the Lifespan of Caenorhabditis elegans
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DOI: 10.1111/acel.70060
Abstract: Analysis of existing lifespan‐extending geroprotective compounds suggested that polypharmacological compounds are the most effective geroprotectors, specifically those that bind multiple biogenic amine receptors. To test this hypothesis, we used graph neural networks to predict polypharmacological… read more here.
Keywords: exceptionally efficacious; polypharmacological compounds; identification exceptionally; driven identification ... See more keywords