Pursuing Polypharmacology: Benzothiopyranoindoles as G-Quadruplex Stabilizers and Topoisomerase I Inhibitors for Effective Anticancer Strategies.
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DOI: 10.1021/acsmedchemlett.4c00313
Abstract: Here, we explored the benzothiopyranoindole scaffold to develop antiproliferative agents with a polypharmacological profile targeting both G-quadruplex (G4)-structures and Topoisomerase (Topo) I enzyme. In a preliminary optimization phase, compound 1 was selected from an in-house… read more here.
Keywords: polypharmacology benzothiopyranoindoles; pursuing polypharmacology; anticancer; quadruplex stabilizers ... See more keywords