Dual Role of Inorganic Polyphosphate (POLYP) in the Regulation of Mitochondria-Dependent Cell Death
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2345
Abstract: Inorganic polyphosphate (polyP) is a ubiquitous biological polymer that is well-conserved throughout the evolution and various species. Isoenergetic with ATP, polyP is composed of multiple subunits of orthophosphate, linked together by phosphoanhydride bonds. PolyP plays… read more here.
Keywords: polyp; inorganic polyphosphate; role; cell death ... See more keywords
Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration?
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105211
Abstract: Mitochondrial dysfunction - including increased apoptosis, calcium and protein dyshomeostasis within the organelle, and dysfunctional bioenergetics and oxidative status - is a common and early feature in all the major neurodegenerative diseases, including Alzheimer's Disease… read more here.
Keywords: polyp; inorganic polyphosphate; neurodegeneration; physiology ... See more keywords
Mitochondrial Inorganic Polyphosphate (polyP) Is a Potent Regulator of Mammalian Bioenergetics in SH-SY5Y Cells: A Proteomics and Metabolomics Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.833127
Abstract: Inorganic polyphosphate (polyP) is an ancient, ubiquitous, and well-conserved polymer which is present in all the studied organisms. It is formed by individual subunits of orthophosphate which are linked by structurally similar bonds and isoenergetic… read more here.
Keywords: polyphosphate polyp; inorganic polyphosphate; physiology; polyp ... See more keywords
Enzymatic Depletion of Mitochondrial Inorganic Polyphosphate (polyP) Increases the Generation of Reactive Oxygen Species (ROS) and the Activity of the Pentose Phosphate Pathway (PPP) in Mammalian Cells
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DOI: 10.3390/antiox11040685
Abstract: Inorganic polyphosphate (polyP) is an ancient biopolymer that is well preserved throughout evolution and present in all studied organisms. In mammals, it shows a high co-localization with mitochondria, and it has been demonstrated to be… read more here.
Keywords: mitoppx cells; ppp; inorganic polyphosphate; mammalian cells ... See more keywords