PPEylation of proteins: Synthesis, activity, and stability of myoglobin-polyphosphoester conjugates
Sign Up to like & getrecommendations! Published in 2018 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2018.09.019
Abstract: Abstract Protein-polymer conjugates are used to treat several diseases. PEGylation, i.e. the modification with poly(ethylene glycol) (PEG) is the currently used strategy. However, due to its non-biodegradability, the design of effective and degradable conjugates is… read more here.
Keywords: activity stability; myoglobin polyphosphoester; polyphosphoester; polyphosphoester conjugates ... See more keywords
Synthesis of an Oxidation-Sensitive Polyphosphoester Bearing Thioether Group for Triggered Drug Release.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b00101
Abstract: In this work, novel amphiphilic diblock copolymers of polyethylene glycol and polyphosphoester with pendant thioether groups, denoted as mPEG- b-PMSPEP, were synthesized through the ring-opening polymerization of functionalized cyclic phosphoester monomer using methoxy poly(ethylene glycol)… read more here.
Keywords: oxidation sensitive; oxidation; polyphosphoester; drug ... See more keywords