Acute generation of reactive oxygen species that induced by doxycycline pretreatment results in rapid cell death in polyphyllin G‐treated osteosarcoma cell lines
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DOI: 10.1002/tox.23757
Abstract: Polyphyllin G, a pennogenyl saponin extracted from Paris polyphylla, has been shown to possess antitumor effects. In this study, we demonstrated that doxycycline, an antibiotic medicine, could significantly enhance the sensitivities of osteosarcoma cell lines… read more here.
Keywords: cell death; cell; osteosarcoma cell; polyphyllin ... See more keywords
Polyphyllin D, a steroidal saponin in Paris polyphylla, induces apoptosis and necroptosis cell death of neuroblastoma cells
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DOI: 10.1007/s00383-017-4069-4
Abstract: PurposeNeuroblastoma is a refractory pediatric malignant solid tumor. The previous studies demonstrated that Polyphyllin D, the main constituent of Paris polyphylla, a traditional Chinese medicine, exerts an anti-tumor effect on many tumors. However, its effects… read more here.
Keywords: neuroblastoma; cell death; cell; paris polyphylla ... See more keywords
Anticancer effect of Polyphyllin Ι in colorectal cancer cells through ROS-dependent autophagy and G2/M arrest mechanisms
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DOI: 10.1080/14786419.2017.1353512
Abstract: Abstract Polyphyllin Ι is a steroidal saponin isolated from the rhizoma of Paris polyphylla. In the present study, we aimed to investigate the anticancer effects of polyphyllin Ι in colorectal cancer and to elucidate the… read more here.
Keywords: colorectal cancer; ros dependent; anticancer; polyphyllin ... See more keywords
High-throughput screening identification of a small-molecule compound that induces ferroptosis and attenuates the invasion and migration of hepatocellular carcinoma cells by targeting the STAT3/GPX4 axis
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DOI: 10.3892/ijo.2023.5490
Abstract: Hepatocellular carcinoma (HCC) is a lethal malignancy. Although considerable efforts have been made in recent years regarding treatments, effective therapeutic drugs for HCC remain insufficient. In the present study, polyphyllin VI was identified as a… read more here.
Keywords: hcc cells; gpx4; induces ferroptosis; polyphyllin ... See more keywords