The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase‐mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Cell Proliferation"
DOI: 10.1111/cpr.12520
Abstract: Drug combination has a promising and potential development prospect in the treatment of various cancers. The objective of this study is to investigate the synergistic mechanisms of polyphyllin VII (PVII) and formosanin C (FC) in… read more here.
Keywords: anticancer effect; effect formosanin; polyphyllin vii; synergistic anticancer ... See more keywords
Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production
Sign Up to like & getrecommendations! Published in 2020 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-020-3077-z
Abstract: Background Osteoporosis is a worldwide severe bone disease. This study aimed to evaluate the effect of polyphyllin VII on the genesis of osteoclasts from bone marrow macrophages (BMMs) and its potentiality as a therapeutic drug… read more here.
Keywords: vii; polyphyllin vii; traf6 src; src pi3k ... See more keywords
Polyphyllin VII as a potential drug for targeting stemness in hepatocellular cancer via STAT3 signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009623666221024103834
Abstract: BACKGROUND At present, the treatment of hepatocellular carcinoma (HCC) is disturbed by the treatment failure and recurrence caused by the residual liver cancer stem cells (CSCs). Therefore, drugs targeting HCC CSCs should be able to… read more here.
Keywords: hcc; stat3 signaling; pp7; polyphyllin vii ... See more keywords