The effect of polyploidization on tree hydraulic functioning.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of botany"
DOI: 10.1002/ajb2.1032
Abstract: PREMISE OF THE STUDY Recent research has highlighted the importance of living tissue in wood. Polyploidization can impact amounts and arrangements of living cells in wood, potentially leading to increased drought tolerance. Tetraploid variants were… read more here.
Keywords: drought induced; vulnerability; gala; induced cavitation ... See more keywords
Polyploidization: Consequences of genome doubling on the evolutionary potential of populations.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of botany"
DOI: 10.1002/ajb2.16029
Abstract: Whole-genome duplication is common in plants and is considered to have a broad range of effects on individuals' phenotypes and genomes, and as an important driver of plant adaptation and speciation. Despite their increased capacity… read more here.
Keywords: consequences genome; genome doubling; heritable variance; evolutionary potential ... See more keywords
Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.05.006
Abstract: Summary Aryl hydrocarbon receptor (AhR) deficiency alters tissue homeostasis. However, how AhR regulates organ maturation and differentiation remains mostly unknown. Liver differentiation entails a polyploidization process fundamental for cell growth, metabolism, and stress responses. Here,… read more here.
Keywords: erk wnt; ahr; liver; wnt catenin ... See more keywords
Hepatitis B virus X protein promotes DNA damage propagation through disruption of liver polyploidization and enhances hepatocellular carcinoma initiation
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0607-3
Abstract: Hepatitis B virus X protein (HBx) contributes to Hepatitis B virus (HBV)-related liver cancer. However, its impact on hepatocyte proliferation and genomic stability remains elusive. We studied the role of HBx expression on the progression… read more here.
Keywords: hepatocellular carcinoma; dna damage; protein; hbx ... See more keywords
Evolutionary dynamics of 3D genome architecture following polyploidization in cotton
Sign Up to like & getrecommendations! Published in 2017 at "Nature Plants"
DOI: 10.1038/s41477-017-0096-3
Abstract: The formation of polyploids significantly increases the complexity of transcriptional regulation, which is expected to be reflected in sophisticated higher-order chromatin structures. However, knowledge of three-dimensional (3D) genome structure and its dynamics during polyploidization remains… read more here.
Keywords: chromatin; polyploidization; genome architecture; cotton ... See more keywords
Genome-wide chromatin accessibility analysis unveils open chromatin convergent evolution during polyploidization in cotton
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209743119
Abstract: Significance Polyploidization may cause reshuffling of gene expression accompanied by changes in chromatin-structure dynamic. In eukaryotes, gene expression is regulated via the complex interplay between transcription factors and cis-regulatory DNA elements (CREs) in regions of… read more here.
Keywords: polyploidization cotton; open chromatin; chromatin; chromatin accessibility ... See more keywords
Acetylome reprograming participates in the establishment of fruit metabolism during polyploidization in citrus.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac442
Abstract: Polyploidization leads to novel phenotypes and is a major force in evolution. However, the relationship between the evolution of new traits and variations in the post-translational modifications (PTM) of proteins during polyploidization has not been… read more here.
Keywords: metabolism; acetylome reprograming; fruit; reprograming participates ... See more keywords
Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance
Sign Up to like & getrecommendations! Published in 2017 at "Immunological Reviews"
DOI: 10.1111/imr.12582
Abstract: Cancer cells are subjected to constant selection by the immune system, meaning that tumors that become clinically manifest have managed to subvert or hide from immunosurveillance. Immune control can be facilitated by induction of autophagy,… read more here.
Keywords: adjuvanticity; cancer cells; cancer; immunosurveillance ... See more keywords
Inhibition of polyploidization in Pten‐deficient livers reduces steatosis
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15384
Abstract: The tumour suppressor PTEN is a negative regulator of the PI3K/AKT signalling pathway. Liver‐specific deletion of Pten in mice results in the hyper‐activation PI3K/AKT signalling accompanied by enhanced genome duplication (polyploidization), marked lipid accumulation (steatosis)… read more here.
Keywords: deficient livers; pten deficient; steatosis; polyploidization pten ... See more keywords
Abstract 6144: Polyploidization enables initial survival of chemotherapy but a progressively increased susceptibility to ferroptosis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6144
Abstract: Once cancer has metastasized it remains incurable owing to evolved resistance to nearly all systemic therapies. Classical views of therapeutic resistance include tumor heterogeneity and genetic instability, but our group and others have identified an… read more here.
Keywords: cell; polyploidization; ferroptosis; cancer ... See more keywords
Alignment of Rutaceae Genomes Reveals Lower Genome Fractionation Level Than Eudicot Genomes Affected by Extra Polyploidization
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.00986
Abstract: Owing to their nutritional and commercial values, the genomes of several citrus plants have been sequenced, and the genome of one close relative in the Rutaceae family, atalantia (Atalantia buxifolia), has also been sequenced. Here,… read more here.
Keywords: rutaceae genomes; rutaceae; genome fractionation; alignment rutaceae ... See more keywords