Inhibition of polyploidization in Pten‐deficient livers reduces steatosis
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DOI: 10.1111/liv.15384
Abstract: The tumour suppressor PTEN is a negative regulator of the PI3K/AKT signalling pathway. Liver‐specific deletion of Pten in mice results in the hyper‐activation PI3K/AKT signalling accompanied by enhanced genome duplication (polyploidization), marked lipid accumulation (steatosis)… read more here.
Keywords: deficient livers; pten deficient; steatosis; polyploidization pten ... See more keywords