Knockdown of Fzr inhibited the growth of Nilaparvata lugens by blocking endocycle.
Sign Up to like & getrecommendations! Published in 2024 at "Pest management science"
DOI: 10.1002/ps.8403
Abstract: BACKGROUND The endocycle can generate cells referred to as 'polyploid'. Fizzy-related protein (Fzr) plays an important role in driving the mitosis-to-endocycle transition. The brown planthopper (BPH), Nilaparvata lugens (Stål), a serious insect pest, feeds exclusively… read more here.
Keywords: salivary glands; polyploidy; bph; knockdown fzr ... See more keywords
A report of intraspecific polyploidy (4x, 6x) in Festuca gigantea (L.) Vill (Family: Poaceae) from Western Himalaya, India and comments on its cyto-geography
Sign Up to like & getrecommendations! Published in 2021 at "Nucleus"
DOI: 10.1007/s13237-020-00347-8
Abstract: Two cytotypes of ‘giant fescue’ sporting gametic chromosome number of n = 14 and n = 21 corresponding to 4x and 6x ploidy level (based on x = 7) were encountered in the various localities in India falling in the Western… read more here.
Keywords: polyploidy festuca; geography; intraspecific polyploidy; report intraspecific ... See more keywords
The Polyploid State Plays a Tumor-Suppressive Role in the Liver.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.01.010
Abstract: Most cells in the liver are polyploid, but the functional role of polyploidy is unknown. Polyploidization occurs through cytokinesis failure and endoreduplication around the time of weaning. To interrogate polyploidy while avoiding irreversible manipulations of essential… read more here.
Keywords: polyploid state; role; state plays; liver polyploid ... See more keywords
Targeting tumor cell senescence and polyploidy as potential therapeutic strategies.
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2020.12.010
Abstract: Senescence is a unique state of growth arrest that develops in response to a plethora of cellular stresses, including replicative exhaustion, oxidative injury, and genotoxic insults. Senescence has been implicated in the pathogenesis of multiple… read more here.
Keywords: senescence; tumor cells; therapeutic strategies; cancer ... See more keywords
Reticulate allopolyploidy and subsequent dysploidy drive evolution and diversification in the cotton family
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62644-7
Abstract: Polyploidy and subsequent post-polyploid diploidization (PPD) are key drivers of plant genome evolution, yet their contributions to evolutionary success remain debated. Here, we analyze the Malvaceae family as an exemplary system for elucidating the evolutionary… read more here.
Keywords: ppd; evolution; history; polyploidy ... See more keywords
Polyploidy and the mitosis path to epidermal cell fate
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1568766
Abstract: The cell cycle mechanisms coordinating proliferation with differentiation in epidermis remain intriguing and somewhat controversial. For decades it was assumed that differentiating keratinocytes underwent growth and cell cycle arrest in G0. This concept was supported… read more here.
Keywords: mitosis; differentiating keratinocytes; differentiation; cell fate ... See more keywords
The direct effects of plant polyploidy on the legume–rhizobia mutualism
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Botany"
DOI: 10.1093/aob/mcx121
Abstract: Background Polyploidy is known to significantly alter plant genomes, phenotypes and interactions with the abiotic environment, yet the impacts of polyploidy on plant-biotic interactions are less well known. A particularly important plant-biotic interaction is the… read more here.
Keywords: plant; legume rhizobia; rhizobia mutualism; plant polyploidy ... See more keywords
Abstract 5725: Aurkin-A, a TPX2-Aurora A inhibitor disrupts alisertib-induced polyploidy in HG-diffuse large B cell lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5725
Abstract: Chemotherapy induced polyploidy (CIP) is a mechanism of inherited drug resistance resulting in an aggressive disease course in cancer patients. Alisertib, an Aurora Kinase A (AK-A) ATP site inhibitor, induces cell cycle disruption resulting in… read more here.
Keywords: induced polyploidy; polyploidy; cell; inhibitor ... See more keywords
A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011605
Abstract: Unscheduled whole genome duplication (WGD), also described as unscheduled or non-physiological polyploidy, can lead to genetic instability and is commonly observed in human cancers. WGD generates DNA damage due to scaling defects between replication factors… read more here.
Keywords: role; polyploidy; repair; cell ... See more keywords
False positivity in break apart fluorescence in-situ hybridization due to polyploidy
Sign Up to like & getrecommendations! Published in 2023 at "Translational Lung Cancer Research"
DOI: 10.21037/tlcr-22-516
Abstract: Background In-situ hybridization (ISH) is a diagnostic tool in the detection of chromosomal anomalies, which has important implications for diagnosis, classification and prediction of cancer therapy in various diseases. Certain thresholds of number of cells… read more here.
Keywords: lung cancer; situ hybridization; polyploidy; break apart ... See more keywords
Impact of polyploidy on plant tolerance to abiotic and biotic stresses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.869423
Abstract: Polyploidy, defined as the coexistence of three or more complete sets of chromosomes in an organism’s cells, is considered as a pivotal moving force in the evolutionary history of vascular plants and has played a… read more here.
Keywords: abiotic biotic; polyploidy; biotic stresses; plant ... See more keywords