Resorting the function of the colorectal cancer gatekeeper adenomatous polyposis coli
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32557
Abstract: As a large number of cancers are caused by nonsense mutations in key genes, read‐through of these mutations to restore full‐length protein expression is a potential therapeutic strategy. Mutations in the adenomatous polyposis coli (APC)… read more here.
Keywords: polyposis coli; number; nonsense mutations; polyposis ... See more keywords
Immunolocalization of adenomatous polyposis coli protein (apc) in the regenerating lizard tail suggests involvement in tissue differentiation and regulation of growth
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Morphology"
DOI: 10.1002/jmor.21465
Abstract: Lizard tail regeneration is likely regulated by the balanced activity of oncogenes and tumor suppressors that control cell proliferation avoiding tumorigenic degeneration. One of the main tumor suppressor genes present in the regenerating tail is… read more here.
Keywords: adenomatous polyposis; lizard tail; protein apc; differentiation ... See more keywords
Prevalence and outcome of comorbidities associated with acromegaly
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-021-04846-8
Abstract: Acromegaly is associated with various comorbidities, such as arterial hypertension (aHT), type 2 diabetes mellitus (DM2), obstructive sleep apnoea syndrome (OSAS), carpal tunnel syndrome (CTS) and polyposis coli. For therapeutic decisions, it is essential to… read more here.
Keywords: polyposis coli; remission; prevalence; associated morbidities ... See more keywords
Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00532
Abstract: Despite advances in targeted anticancer therapies, there are still no small-molecule-based therapies available that specifically target colorectal cancer (CRC) development and progression, the second leading cause of cancer deaths. We previously disclosed the discovery of… read more here.
Keywords: colorectal cancer; chemistry; polyposis coli; coli apc ... See more keywords
Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0267-3
Abstract: The adenomatous polyposis coli (APC) protein has a tumor-suppressor function by acting as a negative regulator of the Wnt signaling pathway. While its role as a tumor suppressor is well-defined, the post-translational modifications that regulate… read more here.
Keywords: catenin; polyposis coli; mkrn1; adenomatous polyposis ... See more keywords
Role of adenomatous polyposis coli in proliferation and differentiation of colon epithelial cells in organoid culture
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83590-6
Abstract: Adenomatous polyposis coli (APC) is a tumor-suppressing protein whose inactivation triggers the formation of colorectal polyps. Numerous studies using cell lines or genetically engineered mice have revealed its role in suppressing Wnt/β-catenin signaling pathway and… read more here.
Keywords: polyposis coli; colon; organoid culture; differentiation ... See more keywords
Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217096120
Abstract: Significance Adenomatosis polyposis coli down-regulated 1 (APCDD1)—a conserved single-span transmembrane protein containing a large extracellular domain—negatively regulates WNT signaling and plays important roles in hair follicle development, CNS vascular development, and glial differentiation. We report… read more here.
Keywords: regulated apcdd1; adenomatosis polyposis; coli regulated; polyposis coli ... See more keywords
The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl5942
Abstract: Adenomatous polyposis coli (APC) is a tumor suppressor whose mutations underlie familial adenomatous polyposis (FAP) and colorectal cancer. Although its role in intestinal epithelial cells is well characterized, APC importance in T cell biology is… read more here.
Keywords: biology; polyposis coli; cell; adenomatous polyposis ... See more keywords
Extracolonic cancer risk in Dutch patients with APC (adenomatous polyposis coli)-associated polyposis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2017-104545
Abstract: Background Screening of patients with familial adenomatous polyposis (FAP) have led to a substantial reduction in mortality due to colorectal cancer (CRC). Recent guidelines suggest that surveillance of non-intestinal malignancies should also be considered in… read more here.
Keywords: polyposis coli; pathology; cancer; polyposis ... See more keywords
Compliance with NCCN screening and chemoprevention recommendations among carriers of deleterious mutations in the adenomatous polyposis coli gene.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.571
Abstract: 571Background: Deleterious mutations in adenomatous polyposis coli gene (APC) lead to familial adenomatous polyposis [FAP] and attenuated FAP (aFAP) syndromes associated with hereditary colorectal cancer (CRC) and extra-colonic neoplasms. Reports suggest only two-third of such… read more here.
Keywords: mutations adenomatous; polyposis coli; deleterious mutations; gene ... See more keywords
The mitotic role of Adenomatous Polyposis Coli requires its bilateral interaction with tubulin and microtubules.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.260152
Abstract: Adenomatous Polyposis Coli (APC) is a scaffold protein with tumour suppressor properties. Mutations causing the loss of its C-terminal domain (APC-C) - bearing cytoskeleton-regulating sequences - correlate with colorectal cancer. The cellular roles of APC… read more here.
Keywords: tubulin microtubules; adenomatous polyposis; bilateral interaction; tubulin ... See more keywords