Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis by regulating fatty acid‐binding protein 5
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14318
Abstract: The activation of cardiac fibroblasts (CFs) leads to overproduction of collagens and subsequently cardiac fibrosis. However, the regulatory mechanism of CF function in the process of cardiac fibrosis remains unclear. This work investigated the function… read more here.
Keywords: binding protein; cardiac fibrosis; polypyrimidine tract; fibrosis ... See more keywords
Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202149257
Abstract: The maturation of immature B cells and the survival of mature B cells is stringently controlled to maintain a diverse repertoire of antibody specificities while avoiding self‐reactivity. At the molecular level this is regulated by… read more here.
Keywords: mature cells; binding proteins; ptbp1 ptbp3; polypyrimidine tract ... See more keywords
Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202149781
Abstract: The RNA-binding protein Polypyrimidine Tract Binding Protein 1 (PTBP1) has been found to have roles in CD4 T cell activation, but its function in CD8 T cells remains untested. We show it is dispensable for… read more here.
Keywords: activation; cd8 cells; polypyrimidine tract; cd8 ... See more keywords
Splicing of long non-coding RNAs primarily depends on polypyrimidine tract and 5′ splice-site sequences due to weak interactions with SR proteins
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1147
Abstract: Abstract Many nascent long non-coding RNAs (lncRNAs) undergo the same maturation steps as pre-mRNAs of protein-coding genes (PCGs), but they are often poorly spliced. To identify the underlying mechanisms for this phenomenon, we searched for… read more here.
Keywords: splicing long; splice; coding rnas; long non ... See more keywords
Widespread Separation of the Polypyrimidine Tract From 3′ AG by G Tracts in Association With Alternative Exons in Metazoa and Plants
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00741
Abstract: At the end of introns, the polypyrimidine tract (Py) is often close to the 3′ AG in a consensus (Y)20NCAGgt in humans. Interestingly, we have found that they could also be separated by purine-rich elements… read more here.
Keywords: metazoa plants; separation polypyrimidine; widespread separation; polypyrimidine tract ... See more keywords
Oncogenic miR-132 sustains proliferation and self-renewal potential by inhibition of polypyrimidine tract-binding protein 2 in glioblastoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.7572
Abstract: Glioblastoma multiforme (GBM) is the leading type of brain tumor, exhibiting unlimited proliferation and invasion potential. The present study indicated that a high expression level of miR-132 was detected in the neural subtype of GBM… read more here.
Keywords: mir 132; gbm; proliferation; binding protein ... See more keywords
Alternative splicing analysis showed the splicing factor polypyrimidine tract-binding protein 1 as a potential target in acute myeloid leukemia therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Neoplasma"
DOI: 10.4149/neo_2022_220314n279
Abstract: Alternative splicing (AS) is a universal post-transcriptional regulation process in cells, and increasing evidences have validated its crucial role in tumors. We collected AS event, gene expression, and clinical data of 178 AML patients from… read more here.
Keywords: factor polypyrimidine; binding protein; tract binding; alternative splicing ... See more keywords
Polypyrimidine tract-binding proteins are essential for B cell development
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.53557
Abstract: Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that… read more here.
Keywords: polypyrimidine tract; cell; essential cell; cell development ... See more keywords