ANDROGEN RECEPTOR WITH SHORT POLYGLUTAMINE TRACT PREFERABLY ENHANCES WNT/β-CATENIN MEDIATED PROSTATIC TUMORIGENESIS
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DOI: 10.1038/s41388-020-1214-7
Abstract: Polyglutamine (polyQ) tract polymorphism within the human androgen receptor (AR) shows population heterogeneity. African American men possess short polyQ tracts significantly more frequently than Caucasian American men. The length of polyQ tracts is inversely correlated… read more here.
Keywords: tumorigenesis; short polyq; catenin; polyq tract ... See more keywords
The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities
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DOI: 10.1038/s41418-021-00914-9
Abstract: Huntington’s disease is caused by a pathologically long (>35) CAG repeat located in the first exon of the Huntingtin gene ( HTT ). While pathologically expanded CAG repeats are the focus of extensive investigations, non-pathogenic… read more here.
Keywords: evolutionary history; huntingtin; polyq tract; tract ... See more keywords
Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biochimica et biophysica Sinica"
DOI: 10.3724/abbs.2023081
Abstract: Nine polyglutamine (polyQ) proteins have already been identified that are considered to be associated with the pathologies of neurodegenerative disorders called polyQ diseases, but whether these polyQ proteins mutually interact and synergize in proteinopathies remains… read more here.
Keywords: polyq proteins; mediated polyq; polyq tract; coaggregation ... See more keywords