Methods for Posttranslational Induction of Polyreactivity of Antibodies.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7180-0_10
Abstract: An antibody molecule that recognizes multiple unrelated antigens is defined as polyreactive. Polyreactivity is an intrinsic characteristic of immune repertoires. Degenerated antigen binding diversifies the repertoire of specificities, thus contributing to immune defense and immune… read more here.
Keywords: posttranslational induction; polyreactivity antibodies; methods posttranslational; induction polyreactivity ... See more keywords
Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity
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DOI: 10.1016/j.celrep.2018.04.101
Abstract: Summary Human high-affinity antibodies to pathogens often recognize unrelated ligands. The molecular origin and the role of this polyreactivity are largely unknown. Here, we report that HIV-1 broadly neutralizing antibodies (bNAbs) are frequently polyreactive, cross-reacting… read more here.
Keywords: conformational plasticity; non hiv; hiv; polyreactivity ... See more keywords
Sequence features of variable region determining physicochemical properties and polyreactivity of therapeutic antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.06.012
Abstract: Therapeutic antibodies have transformed the clinical practice. Not surprisingly, development of antibody therapeutics is currently the main focus of the biotechnology industry. Nonetheless, the development process is complex, and many antibodies do not reach the… read more here.
Keywords: therapeutic antibodies; features variable; polyreactivity; variable region ... See more keywords