Biochemical Characterization and Analyses of Polysialic‐Acid‐Associated Carrier Proteins and Genes in Piglets during Neonatal Development
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700029
Abstract: Polysialic acid plays a key role in cancer metastasis and neurodevelopment. Our aim was to determine the developmental gene‐expression profiles for the two polysialyltransferases ST8Sia II and ST8Sia IV, neural cell‐adhesion molecules (NCAMs), SynCAM 1, neuropilin‐2 (NRP2) and… read more here.
Keywords: polysialic acid; st8sia st8sia; carrier proteins; brain ... See more keywords
Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03601-z
Abstract: Polysialic acid (polySia) emerges as a novel regulator of microglia activity. We recently identified polysialylated proteins in the Golgi compartment of murine microglia that are released in response to inflammatory stimulation. Since exogenously added polySia… read more here.
Keywords: siglec; polysialic acid; response; polysia ... See more keywords
Polycaprolactone/polysialic acid hybrid, multifunctional nanofiber scaffolds for treatment of spinal cord injury.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.06.038
Abstract: Scaffold-based tissue engineering is widely used for spinal cord injury (SCI) treatment by creating supporting and guiding neuronal tissue regeneration. However, how to enhance the axonal regeneration capacity following SCI still remains a challenge. Polysialic… read more here.
Keywords: psa; polysialic acid; treatment; cord injury ... See more keywords
Recent advances in the analysis of polysialic acid from complex biological systems.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115145
Abstract: Polysialic acid (polySia) is a unique, well-characterised carbohydrate polymer highly-expressed on the cell surface of neurons in the early stages of mammalian brain development. Post-embryogenesis, it is also re-expressed in a number of tumours of… read more here.
Keywords: recent advances; cell; polysialic acid; polysia ... See more keywords
Polysialic acid-mediated activity measurement of polysialylated recombinant coagulation factor VIII.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.10.019
Abstract: Measurement of modified biologic including coagulation factors with extended half-life obtained for example by polysialylation pose an analytical challenge especially if both biological activity and presence of modification have to be determined. Analytical methods applied… read more here.
Keywords: polysialic acid; acid mediated; factor viii; polysialylated recombinant ... See more keywords
Brain region-dependent alterations in polysialic acid immunoreactivity across the estrous cycle in mice
Sign Up to like & getrecommendations! Published in 2020 at "Hormones and Behavior"
DOI: 10.1016/j.yhbeh.2020.104851
Abstract: N-glycosylation is a posttranslational modification that plays significant roles in regulating protein function. One form of N-glycosylation, polysialylation, has been implicated in many processes including learning and memory, addiction, and neurodegenerative disease. Polysialylation appears to… read more here.
Keywords: polysialic acid; across estrous; psa immunoreactivity; cycle ... See more keywords
Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46240-6
Abstract: Stress is an important environmental factor influencing human behaviour and causing several mental disorders. Alterations in the structure of polysialic acid (polySia/PSA) due to genetic alterations in ST8SIA2, which encodes a polySia-synthesizing enzyme, are related… read more here.
Keywords: polysialic acid; acute stress; stress; brain ... See more keywords
Transposable Element Insertions into the Escherichia coli Polysialic Acid Gene Cluster Result in Resistance to the K1F Bacteriophage
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02112-21
Abstract: Bacteriophages have many potential uses in industry and the clinical environment as an antibacterial control measure. One of their uses, phage therapy, is an appealing alternative to antibiotics due to their high specificity. ABSTRACT Reviewing… read more here.
Keywords: escherichia coli; k1f; k1f bacteriophage; polysialic acid ... See more keywords
News and Views on Polysialic Acid: From Tumor Progression and Brain Development to Psychiatric Disorders, Neurodegeneration, Myelin Repair and Immunomodulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.871757
Abstract: Polysialic acid (polySia) is a sugar homopolymer consisting of at least eight glycosidically linked sialic acid units. It is a posttranslational modification of a limited number of proteins with the neural cell adhesion molecule NCAM… read more here.
Keywords: brain development; polysialic acid; brain; polysia ... See more keywords
Polysialic Acid in the Immune System
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.823637
Abstract: Polysialic acid (polySia) is a highly regulated polymer of sialic acid (Sia) with such potent biophysical characteristics that when expressed drastically influences the interaction properties of cells. Although much of what is known of polySia… read more here.
Keywords: system; acid immune; polysialic acid; polysia ... See more keywords
Polysialic Acid Sustains the Hypoxia-Induced Migration and Undifferentiated State of Human Glioblastoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179563
Abstract: Gliomas are the most common primary malignant brain tumors. Glioblastoma, IDH-wildtype (GBM, CNS WHO grade 4) is the most aggressive form of glioma and is characterized by extensive hypoxic areas that strongly correlate with tumor… read more here.
Keywords: hypoxia induced; polysialic acid; sustains hypoxia; migration ... See more keywords