Accessing Polysubstituted NH Pyrroles from Nitroalkenes via [4+2]‐Cycloaddition/Reductive Ring Contraction Strategy
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400627
Abstract: A novel two‐step access to polysubstituted pyrroles from nitroalkenes was developed. It involves [4+2]‐cycloaddition with enol ethers to give six‐membered cyclic nitronates followed by reductive ring contraction with Ra‐Ni/AcOH or Ra‐Ni/EtOH systems. The process is… read more here.
Keywords: ring contraction; polysubstituted pyrroles; pyrroles nitroalkenes; reductive ring ... See more keywords
DBU-promoted tandem Michael-addition/cyclization for the synthesis of polysubstituted pyrroles
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.02.057
Abstract: Abstract An efficient and transition-metal-free method for the synthesis of the structurally diversified pyrroles is described. Various α,β-unsaturated ynones reacted with N-substituted ethyl glycine ethyl ester hydrochlorides in the presence of DBU to form the… read more here.
Keywords: synthesis; promoted tandem; polysubstituted pyrroles; synthesis polysubstituted ... See more keywords
Copper-Catalyzed Synthesis of Polysubstituted Pyrroles through [3+1+1] Cycloaddition Reaction of Nitrones and Isocyanides.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00798
Abstract: An efficient, copper-catalyzed [3+1+1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting polysubstituted pyrroles from easily available nitrones and α-acidic isocyanides. The given approach features a new mode of cycloaddition between nitrones… read more here.
Keywords: polysubstituted pyrroles; nitrones isocyanides; cycloaddition; reaction ... See more keywords
Visible-light-mediated synthesis of polysubstituted pyrroles via CAr-I reduction triggered 1,5-hydrogen atom transfer process
Sign Up to like & getrecommendations! Published in 2024 at "Organic Chemistry Frontiers"
DOI: 10.1039/d4qo00953c
Abstract: A novel strategy for the construction of polysubstituted pyrroles has been developed through visible-light induced single-electron reduction of CAr-I bonds and the following 1,5-hydrogen atom transfer (HAT) process. This protocol... read more here.
Keywords: visible light; hydrogen atom; car; reduction ... See more keywords