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   Articles with "polyubiquitin" as a keyword



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Synthesis and purification of linkage-specific polyubiquitin chains of distinct length for structural studies.

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recommendations! Published in 2018 at "Analytical biochemistry"

DOI: 10.1016/j.ab.2018.08.007

Abstract: Polyubiquitylation is one of the most versatile post-translational modifications involved in the regulation of numerous intracellular signaling processes. An assembly procedure that is simple, robust, and efficient to synthesize and purify linkage-specific polyubiquitin chains of… read more here.

Keywords: structural studies; linkage specific; polyubiquitin chains; specific polyubiquitin ... See more keywords
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The Cellular Location of Rad23, a Polyubiquitin Chain-Binding Protein, Plays a Key Role in its Interaction with Substrates of the Proteasome.

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recommendations! Published in 2020 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2020.03.001

Abstract: Well-studied structural motifs in Rad23 have been shown to bind polyubiquitin chains and the proteasome. These domains are predicted to enable Rad23 to transport polyubiquitylated (polyUb) substrates to the proteasome (Chen and Madura, 2002 [1]).… read more here.

Keywords: protein; export; rad23; location rad23 ... See more keywords
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Identification of linear polyubiquitin chain immunoreactivity in tau pathology of Alzheimer’s disease

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recommendations! Published in 2019 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2019.03.017

Abstract: Characteristic neuropathological structures observed in Alzheimer's disease, such as neurofibrillary tangles and dystrophic neurites of senile plaques, are universally ubiquitinated. Eight linkage types of polyubiquitin chains are known, and each type of chain exerts different… read more here.

Keywords: chain; linear polyubiquitin; alzheimer disease; pathology ... See more keywords
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SUMO enhances unfolding of SUMO–polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2213703120

Abstract: Significance Protein quality control pathways enhance protein activities by promoting maturation, preventing aggregation, or by targeting proteins or protein complexes for degradation by pathways such as the ubiquitin–proteasome pathway. Ubiquitin and ubiquitin-like protein SUMO conjugation… read more here.

Keywords: ufd1 npl4; polyubiquitin; sumo polyubiquitin; npl4 cdc48 ... See more keywords
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Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62

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recommendations! Published in 2018 at "Autophagy"

DOI: 10.1080/15548627.2017.1407889

Abstract: ABSTRACT Ubiquitin chains are formed with 8 structurally and functionally distinct polymers. However, the functions of each polyubiquitin remain poorly understood. We developed a polyubiquitin-mediated fluorescence complementation (PolyUb-FC) assay using Kusabira Green (KG) as a… read more here.

Keywords: sqstm1 p62; polyub; linked polyubiquitin; k33 linked ... See more keywords