Organ defects of the Usp7K444R mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation.
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DOI: 10.1016/j.bj.2022.02.002
Abstract: BACKGROUND K63-linked polyubiquitination of proteins have nonproteolytic functions and regulate the activity of many signal transduction pathways. USP7, a HIF1α deubiquitinase, undergoes K63-linked polyubiquitination under hypoxia. K63-polyubiquitinated USP7 serves as a scaffold to anchor HIF1α,… read more here.
Keywords: organ defects; polyubiquitinated usp7; k63 polyubiquitinated; role ... See more keywords