Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22495
Abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein crucial for repair of oxidized DNA damage not only in genomic DNA but also in mitochondrial DNA. Parkin, a tumor suppressor and Parkinson's disease (PD) associated gene,… read more here.
Keywords: polyubiquitination; ape1; apurinic apyrimidinic; parkin ... See more keywords
TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.07.021
Abstract: Summary Polyubiquitination of proliferating cell nuclear antigen (PCNA) regulates the error-free template-switching mechanism for the bypass of DNA lesions during DNA replication. PCNA polyubiquitination is critical for the maintenance of genomic integrity; however, the underlying… read more here.
Keywords: response dna; dna damage; polyubiquitination; pcna polyubiquitination ... See more keywords
Ubc13-UEV mediated K63-linked polyubiquitination in plants.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac239
Abstract: Ubiquitination is one of the best known post-translational modifications in eukaryotes, in which different linkage types of polyubiquitination result in different outputs of the target proteins. Distinct from the well-characterized K48-linked polyubiquitination that usually serves… read more here.
Keywords: linked polyubiquitination; polyubiquitination; ubc13 uev; uev mediated ... See more keywords
Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky943
Abstract: Abstract DNA-damage tolerance protects cells via at least two sub-pathways regulated by proliferating cell nuclear antigen (PCNA) ubiquitination in eukaryotes: translesion DNA synthesis (TLS) and template switching (TS), which are stimulated by mono- and polyubiquitination,… read more here.
Keywords: hltf; damage tolerance; polyubiquitination; choice ... See more keywords
TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz537
Abstract: Abstract The multifunctional human DNA2 (hDNA2) nuclease/helicase is required to process DNA ends for homology-directed recombination repair (HDR) and to counteract replication stress. To participate in these processes, hDNA2 must localize to the nucleus and… read more here.
Keywords: nuclear localization; human dna2; maintain nuclear; polyubiquitination ... See more keywords
TGFβ activates PI3K-AKT signaling via TRAF6
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22275
Abstract: Deregulation of the PI3K/AKT pathway has been reported in many types of cancer, including prostate cancer. As AKT regulates survival, metabolism, migration and therapy resistance in cancer cells, aberrant, high activity of AKT is involved… read more here.
Keywords: traf6; polyubiquitination p85; pi3k akt; polyubiquitination ... See more keywords
Atypical Ubiquitination and Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073705
Abstract: Ubiquitination (the covalent attachment of ubiquitin molecules to target proteins) is one of the main post-translational modifications of proteins. Historically, the type of polyubiquitination, which involves K48 lysine residues of the monomeric ubiquitin, was the… read more here.
Keywords: parkinson disease; polyubiquitination; atypical ubiquitination; ubiquitination ... See more keywords