Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units.
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DOI: 10.1021/jacs.7b00607
Abstract: Targeting DNA G-quadruplexes using small-molecule ligands has shown to modulate biological functions mediated by G-quadruplexes inside cells. Given >716 000 G-quadruplex hosting sites in human genome, the specific binding of ligands to quadruplex becomes problematic. Here,… read more here.
Keywords: induced unstacking; polyvalency; polyvalency induced; binding units ... See more keywords