Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism
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DOI: 10.1080/10717544.2020.1754524
Abstract: Abstract Sinomenine (SIN) is an anti-inflammatory alkaloid derived from Sinomenium acutum, and the products sinomenine hydrochloride (SH) tablets and injections have been marketed in China to treat rheumatoid arthritis (RA). Oral administration of SH has… read more here.
Keywords: polyvinylpyrrolidone microneedles; penetration; delivery; microneedles localized ... See more keywords