POMC maintains tumor‐initiating properties of tumor tissue‐derived long‐term‐cultured breast cancer stem cells
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30658
Abstract: The identification and understanding of the molecular network of cancer stem cells (CSCs) have had a profound impact on our view of carcinogenesis and treatment strategy. Unfortunately, a major problem is that serial passages of… read more here.
Keywords: cancer stem; breast; pomc; bcsc ... See more keywords
Effect of coatings on thermal conductivity and tribological properties of aluminum foam/polyoxymethylene interpenetrating composites
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Materials Science"
DOI: 10.1007/s10853-019-03826-9
Abstract: The purpose of this work is to solve the problem of interface bonding in aluminum foam (AF)/polyoxymethylene (POM) interpenetrating phase composites (AF/POM). Silane coupling agent (KH-550), graphene oxide (GO), sulfonated graphene (S-GNS) and graphene (GS)… read more here.
Keywords: aluminum foam; pomc; thermal conductivity; foam polyoxymethylene ... See more keywords
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.09.024
Abstract: Summary Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear. Here, we demonstrate that leptin-induced depolarization of POMC neurons is associated with the augmentation of a voltage-gated… read more here.
Keywords: leptin; pomc; glucose production; pro opiomelanocortin ... See more keywords
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.034
Abstract: Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin (POMC)-expressing neurons. Here, we demonstrate that inactivation of apoptosis-inducing factor (AIF) in POMC neurons mildly impairs mitochondrial respiration and decreases firing… read more here.
Keywords: pomc neurons; fatty acid; pomc; obesity ... See more keywords
Alcohol consumption preferentially activates a subset of pro-opiomelanocortin (POMC) producing neurons targeting the amygdala
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108674
Abstract: BACKGROUND Alcohol abuse is a worldwide public health concern and leads to an estimated 90,000 alcohol-related deaths in the United States annually. Alcohol may promote its euphoric and motivational effects, in part, by activating the… read more here.
Keywords: neurons targeting; producing neurons; pomc; pomc producing ... See more keywords
Growth Hormone Receptor Deletion Reduces the Density of Axonal Projections from Hypothalamic Arcuate Nucleus Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.03.037
Abstract: The arcuate nucleus (ARH) is an important hypothalamic area for the homeostatic control of feeding and other metabolic functions. In the ARH, proopiomelanocortin- (POMC) and agouti-related peptide (AgRP)-expressing neurons play a key role in the… read more here.
Keywords: arcuate nucleus; pomc; density; growth hormone ... See more keywords
PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2016.12.021
Abstract: Summary We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of these cells in modeling of a monogenic form of severe… read more here.
Keywords: hypothalamic neurons; pomc; stem cell; stem ... See more keywords
DNA Methylation of POMC and NR3C1-1F and Its Implication in Major Depressive Disorder and Electroconvulsive Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacopsychiatry"
DOI: 10.1055/a-2034-6536
Abstract: Abstract Introduction Precision medicine in psychiatry is still in its infancy. To establish patient-tailored treatment, adequate indicators predicting treatment response are required. Electroconvulsive therapy (ECT) is considered one of the most effective options for pharmacoresistant… read more here.
Keywords: pomc; dna methylation; electroconvulsive therapy; depressive disorder ... See more keywords
Uneven balance of power between hypothalamic peptidergic neurons in the control of feeding
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1802237115
Abstract: Significance The interplay between the anorexigenic and orexigenic neurons in the arcuate nucleus that contributes to the control of feeding remains elusive. Using optogenetic stimulation, we show that activation of POMC neurons rapidly inhibits feeding… read more here.
Keywords: control feeding; pomc neurons; pomc; orexigenic neurons ... See more keywords
Risk factors of myasthenic crisis after thymectomy for thymoma patients with myasthenia gravis†
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Cardio-Thoracic Surgery"
DOI: 10.1093/ejcts/ezx163
Abstract: OBJECTIVES Total thymectomy should be performed on thymoma patients with myasthenia gravis. The aim of the present study was to investigate the risk factors of postoperative myasthenic crisis (POMC) occurrence in these patients. METHODS The… read more here.
Keywords: myasthenic crisis; patients myasthenia; pomc; thymoma patients ... See more keywords
Energy state alters regulation of proopiomelanocortin neurons by glutamatergic ventromedial hypothalamus neurons: pre- and post-synaptic mechanisms.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurophysiology"
DOI: 10.1152/jn.00359.2020
Abstract: To maintain metabolic homeostasis, motivated behaviors are driven by neuronal circuits that process information encoding the animal's energy state. Such circuits likely include ventromedial hypothalamus (VMH) glutamatergic neurons that project throughout the brain to drive… read more here.
Keywords: state; energy state; energy; food intake ... See more keywords